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Differential off-target glucocorticoid activity of progestins used in endocrine therapy.

Author: AfricanderDonita J, AvenantChanel, HapgoodJanet P, KomaneMaleshigo, Louw-du ToitRenate

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study compared the glucocorticoid receptor (GR) activity of several progestins commonly used in endocrine therapy. The results suggest that MPA is likely to have GR-mediated side effects, while ETG and NES may have selective effects, and LNG and NET are unlikely to have significant GR activity.
Paper Details　
Original Abstract of the Article :
The glucocorticoid receptor (GR) regulates transcription of genes involved in multiple processes. Medroxyprogesterone acetate (MPA), widely used in the injectable contraceptive Depo-MPA (DMPA), has off-target effects via the GR, which may result in side-effects in endocrine therapy. However, very li...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35271867

データ提供：米国国立医学図書館（NLM）

Glucocorticoid Activity of Progestins: A Journey Through the Desert of Hormone Therapy

[Progestins] are often used in [endocrine therapy], but like a desert oasis, they can sometimes have unexpected effects on the body. This study examines the [glucocorticoid receptor (GR)] activity of various progestins, exploring their potential for causing side effects.

Navigating the Desert of Hormones: Understanding GR Activity

The study found that different progestins exhibit varying degrees of GR activity, with some displaying significant agonist activity, while others have minimal or no effect. This finding highlights the potential for differential side effects associated with different progestins.

A Journey Through the Desert of Hormone Therapy: Making Informed Choices

This research emphasizes the importance of understanding the specific GR activity of individual progestins to inform treatment decisions and minimize the risk of adverse effects. It underscores the need for careful consideration of the potential side effects associated with different progestins.

Dr. Camel's Conclusion

This study provides valuable insights into the GR activity of various progestins. The findings highlight the importance of considering the potential for differential side effects associated with different progestins and the need for personalized treatment approaches.
Date :
  1. Date Completed 2022-04-19
  2. Date Revised 2023-06-02
Further Info :

Pubmed ID

35271867

DOI: Digital Object Identifier

NIHMS1788136

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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