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Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition.

Author: FujitsukaNaoki, IizukaSeiichi, MogamiSachiko, NahataMiwa, OhbuchiKatsuya, OhnishiShunsuke, SekineHitomi, ShimoboriChika, TakedaHiroshi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored the impact of aging on locomotor activity and liver metabolic function in food-restricted (FR) mice, investigating the involvement of hepatic mitochondria. The findings suggest that aging may impair mitochondrial function, leading to decreased locomotor activity, while a traditional Japanese medicine, hochuekkito (HET), may offer therapeutic benefits.
Paper Details　
Original Abstract of the Article :
Malnutrition impairs basic daily activities and leads to physical frailty, which is aggravated in the elderly compared with young adults. It is also well-known that the elderly are more vulnerable to metabolic stress. Therefore, in this study, using a food restricted (FR) mouse, we aimed to evaluate...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921682/

データ提供：米国国立医学図書館（NLM）

Restoring Liver Mitochondrial Function in Malnourished Aged Mice: The Role of Hochuekkito

Aging is a natural process, but malnutrition can exacerbate the effects of aging, impacting both physical and metabolic health. This study explores the effects of aging and malnutrition on liver mitochondrial function in mice and investigates the potential therapeutic benefits of hochuekkito (HET), a traditional Japanese medicine.

Mitochondrial Function and Aging: A Delicate Oasis

The study revealed that aged mice under food restriction exhibited a decline in liver mitochondrial function, leading to decreased locomotor activity and alterations in metabolic pathways. However, treatment with HET partially restored these functions and improved locomotor activity, suggesting that HET may play a role in mitigating the negative effects of aging and malnutrition.

A Promising Oasis for Age-Related Metabolic Decline: Hochuekkito

This study offers a promising glimpse into the potential of traditional medicine in addressing age-related metabolic decline. The findings suggest that enhancing liver mitochondrial function through approaches like HET treatment could potentially improve overall health and well-being in older individuals.

Dr. Camel's Conclusion

This study highlights the importance of maintaining mitochondrial function in aging, particularly in the context of malnutrition. Hochuekkito emerges as a potential therapeutic agent for mitigating age-related metabolic decline, offering a glimmer of hope in the desert of aging.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-19
Further Info :

Pubmed ID

35299665

DOI: Digital Object Identifier

PMC8921682

SNS
PICO Info
in preparation
Languages

English

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