Effects of capecitabine as part of neo-/adjuvant chemotherapy - A meta-analysis of individual breast cancer patient data from 13 randomised trials including 15,993 patients.

Author: BarriosCarlos H, BearHarry D, JoensuuHeikki, LoiblSibylle, MartinMiguel, MirallesJuan J, MussHyman, MöbusVolker, NekljudovaValentina, NitzUlrike, O'ShaughnessyJoyce, ReimerToralf, SeitherFenja, StegerGuenther G, ToiMasakazu, UntchMichael, van MackelenberghMarion T

Paper Details 
Original Abstract of the Article :
Despite the large number of patients with early breast cancer (EBC) who have been treated with capecitabine in randomised trials, no individual patient data meta-analysis has been conducted. The primary objective was to examine the effect of capecitabine on disease-free survival (DFS), and the secon...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.ejca.2022.02.003

データ提供:米国国立医学図書館(NLM)

Capecitabine's Role in Early Breast Cancer Treatment

Early breast cancer is a significant challenge in medicine, and finding effective treatments is crucial for patients’ well-being. This study analyzes the vast data from 13 randomized trials, involving 15,993 patients, to assess the impact of capecitabine (a chemotherapy drug) on disease-free survival (DFS) in early breast cancer. It’s a journey through mountains of data, seeking the hidden truths of capecitabine’s effectiveness, akin to a caravan crossing a vast desert landscape in search of a valuable oasis.

Capecitabine: A Valuable Tool for Early Breast Cancer

The meta-analysis revealed that capecitabine significantly improved DFS in patients with early breast cancer. It’s like discovering a wellspring of hope in a dry and barren landscape. While the study also looked at distant DFS, overall survival, and pathological complete response, the key finding was the positive effect on DFS.

Navigating the Desert of Breast Cancer Treatment

This research offers crucial insights into the role of capecitabine in treating early breast cancer. It’s a reminder that even in the vast and challenging desert of cancer research, new discoveries and effective treatments can be found. As with any treatment, it is important to consult with healthcare professionals to determine the best course of action for individual patients.

Dr. Camel's Conclusion

The meta-analysis provides compelling evidence that capecitabine plays a significant role in improving survival outcomes for patients with early breast cancer. It’s like finding a precious pearl in the vast expanse of the desert – a testament to the ongoing quest for effective treatments in the battle against cancer.

Date :
  1. Date Completed 2022-04-26
  2. Date Revised 2022-05-12
Further Info :

Pubmed ID

35305453

DOI: Digital Object Identifier

10.1016/j.ejca.2022.02.003

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.