Paper Details
- Home
- Paper Details
Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders.
Author: BurnellKim, DeAlok, GrasingKen W
Original Abstract of the Article :
Lorcaserin is a modestly selective agonist for 2C serotonin receptors (5-HT2CR). Despite early promising data, it recently failed to facilitate cocaine abstinence in patients and has been compared with dopamine antagonist medications (antipsychotics). Here, we review the effects of both classes on d...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/35324488
データ提供:米国国立医学図書館(NLM)
Lorcaserin and Drug Abuse: Exploring the Landscape of Reward
The brain's reward system is a complex and fascinating desert, full of intricate pathways and hidden oases. This research explores the effects of lorcaserin, a serotonin receptor agonist, on reward behavior, comparing its effects to those of drugs of abuse and dopamine antagonists. The study aims to understand the biphasic nature of reward effects and its implications for treating substance use disorders.Biphasic Reward Effects: A Complex Terrain
The research reveals that both lorcaserin and drugs of abuse can produce biphasic effects on reward behavior, with lower doses potentially enhancing drug taking and higher doses leading to reductions. This complex interplay is like the shifting sands of a desert, where the landscape can change dramatically depending on the dose or the context.Potential Implications for Treatment: Navigating the Desert of Addiction
The study's findings have significant implications for the treatment of substance use disorders. Understanding the biphasic nature of reward effects could help tailor treatment strategies to optimize outcomes and minimize the risk of unintended consequences. This knowledge is like having a reliable guide who can navigate the treacherous terrain of addiction and lead patients toward a healthier path.Dr.Camel's Conclusion
This research delves into the complex world of reward behavior, highlighting the biphasic effects of both lorcaserin and drugs of abuse. This intricate interplay of reward and inhibition offers valuable insights for developing more effective treatments for substance use disorders, providing a beacon of hope in the ongoing battle against addiction.Date :
- Date Completed 2022-05-30
- Date Revised 2023-09-14
Further Info :
Related Literature
Article Analysis
SNS
PICO Info
in preparation
Languages
English
Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.