Mitigation of benznidazole toxicity and oxidative stress following ascorbic acid supplementation in an adult traveller with chronic indeterminate Chagas' disease.

Author: BreynaertAnnelies, De BruyneTess, HermansNina, HuitsRalph, TruyensCarine, Van Den BrouckeSteven, Van EsbroeckMarjan, Van HerrewegheMaxim

Paper Details 
Original Abstract of the Article :
BACKGROUND: Benznidazole is an effective drug in the trypanocidal treatment of acute and chronic indeterminate Chagas' disease (CD). However, adverse drug reactions (ADR) are common and frequently cause patients to discontinue treatment. OBJECTIVES: We hypothesized that antioxidant supplementation ...See full text at original site
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引用元:
https://doi.org/10.1093/jac/dkac093

データ提供:米国国立医学図書館(NLM)

Fighting Chagas' Disease: Benznidazole Toxicity and Ascorbic Acid

The fight against [Chagas' disease] is often hampered by the side effects of its primary treatment, [benznidazole]. This study explores the potential of [ascorbic acid] supplementation as a way to mitigate these adverse effects. The authors investigated the impact of [ascorbic acid] on [oxidative stress] in a patient experiencing [benznidazole toxicity], focusing on various biomarkers of oxidative stress. The findings suggest that [ascorbic acid] could be a valuable tool in improving patient tolerance and adherence to [benznidazole] treatment.

Ascorbic Acid: A Potential Ally in Chagas' Disease Treatment

The study provides compelling evidence that [ascorbic acid] may be a helpful strategy to mitigate the [toxicity] associated with [benznidazole]. This is significant because it could increase treatment adherence and potentially lead to better outcomes for patients. However, further research is needed to confirm these findings and explore the optimal dosage and duration of [ascorbic acid] supplementation.

Protecting Your Health: A Balanced Approach

Maintaining a healthy lifestyle, including a balanced diet rich in antioxidants, is essential for overall well-being. This study underscores the importance of understanding the potential benefits and risks associated with various treatments. Always consult with a healthcare professional to discuss any concerns and make informed decisions about your health. Remember, a collaborative approach with your healthcare team is key to achieving optimal health outcomes.

Dr. Camel's Conclusion

This study is like a cool breeze in the desert, offering a refreshing perspective on the management of [Chagas' disease]. The potential of [ascorbic acid] to mitigate the [toxicity] of [benznidazole] is encouraging. However, like a camel crossing a vast expanse, we must continue to explore and research this approach to find a safe and effective solution for those battling this challenging disease.

Date :
  1. Date Completed 2022-06-02
  2. Date Revised 2022-06-03
Further Info :

Pubmed ID

35325159

DOI: Digital Object Identifier

10.1093/jac/dkac093

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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