The effect of low-dose hydrochlorothiazide on blood pressure, serum potassium, and lipoproteins.

Author: AycockD G, GoodmanR P, KingM E, McKenneyJ M, RifaiN, WrightJ T

Paper Details 
Original Abstract of the Article :
Recent clinical trials in hypertension suggest that thiazide diuretics may increase coronary heart deaths in selected patients, possibly through adverse effects on serum potassium, lipids, lipoproteins, and/or apolipoproteins. Administration of smaller doses of diuretics has been recommended to decr...See full text at original site
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引用元:
https://doi.org/10.1002/j.1875-9114.1986.tb03473.x

データ提供:米国国立医学図書館(NLM)

Low-Dose Hydrochlorothiazide: Navigating the Trade-Offs in Hypertension Treatment

Hypertension, a common condition characterized by high blood pressure, can be a challenging health concern. This research explores the effects of low-dose hydrochlorothiazide, a thiazide diuretic, on blood pressure, serum potassium, and lipoproteins in hypertensive patients. It's like navigating a desert landscape, where every decision has consequences, and finding the right balance can be crucial for survival.

Low-Dose Hydrochlorothiazide's Effects on Blood Pressure and Lipids

The study found that both low and high doses of hydrochlorothiazide effectively reduced blood pressure. However, the high dose led to a decrease in serum potassium, while the low dose did not. Interestingly, both doses produced similar increases in total cholesterol, LDL cholesterol, and other lipid parameters. It's like finding a hidden oasis with refreshing water, but discovering that the oasis is surrounded by prickly cacti that could cause harm if not handled carefully.

Balancing the Benefits and Risks

The findings highlight the need to balance the benefits and risks of thiazide diuretics in hypertension management. While low doses can effectively control blood pressure without compromising potassium levels, they can still lead to adverse changes in lipid profiles. As Dr. Camel, I'm always reminding my fellow travelers in the desert of health to consider the potential downsides of every step they take. It's important to understand the full impact of our choices, especially when navigating the complex terrain of chronic diseases.

Dr.Camel's Conclusion

This study underscores the importance of considering the potential risks and benefits of low-dose hydrochlorothiazide in hypertension management. While it effectively reduces blood pressure, the adverse effects on lipid profiles should be taken into account, emphasizing the need for careful monitoring and individualized treatment plans. It's a reminder that even in the seemingly straightforward world of hypertension treatment, there are often nuances and complexities that require careful consideration.

Date :
  1. Date Completed 1986-11-25
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

3534801

DOI: Digital Object Identifier

10.1002/j.1875-9114.1986.tb03473.x

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PICO Info
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Languages

English

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