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Biodegradable and biocompatible subcutaneous implants consisted of pH-sensitive mebendazole-loaded/folic acid-targeted chitosan nanoparticles for murine triple-negative breast cancer treatment.
Author: GhahremaniFatemeh, HosseiniMaryam, JolfaieNafise Arbab, KefayatAmirhosein, RafieniaMohammad
Original Abstract of the Article :
Mebendazole (MBZ) is a well-known anti-parasite drug with significant anti-cancer properties. However, MBZ exhibits low solubility, limited absorption efficacy, extensive first-pass effect, and low bioavailability. Therefore, multiple oral administration of high dose MBZ is required daily for achiev...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973744/
データ提供:米国国立医学図書館(NLM)
Mebendazole: A New Hope in the Battle Against Triple-Negative Breast Cancer
Triple-negative breast cancer is a particularly aggressive form of cancer, challenging oncologists with its resistance to conventional therapies. This study, published in the journal 'International Journal of Pharmaceutics,' explores a new approach to fighting this disease, using mebendazole, a drug traditionally used for parasite infections.A New Oasis: Mebendazole Shows Promise in Triple-Negative Breast Cancer Treatment
This research, like a hidden oasis in the desert of cancer treatment, reveals the promising potential of mebendazole in combating triple-negative breast cancer. The study suggests that mebendazole, encapsulated in pH-sensitive, folic acid-targeted chitosan nanoparticles, can effectively target and destroy cancer cells, offering a new weapon in the battle against this challenging disease. This discovery is like finding a rare and potent herb in the desert, capable of healing a previously incurable wound.A New Frontier in Cancer Treatment: Harnessing the Power of Mebendazole
This study opens up a new frontier in cancer treatment, highlighting the potential of repurposing existing drugs for new applications. The findings suggest that mebendazole, when delivered in a targeted and controlled manner, could offer a valuable weapon against triple-negative breast cancer. This research is like a skilled traveler utilizing local resources to overcome obstacles, demonstrating the importance of exploring new possibilities in the desert of medicine.Dr. Camel's Conclusion
This study offers a glimmer of hope in the fight against triple-negative breast cancer, demonstrating the potential of mebendazole as a novel and effective treatment option. The findings underscore the importance of exploring new approaches and repurposing existing drugs to combat this challenging disease. As we continue to traverse the desert of cancer research, we may discover even more unexpected and promising therapies, bringing us closer to a cure for this formidable foe.Date :
- Date Completed 2022-04-04
- Date Revised 2022-04-05
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