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Effects of Concomitant Administration of PXR Ligand Drugs on the Anticoagulant Effects of Warfarin.
Author: HironoKeiichi, IchidaFukiko, IdeHaruka, MitoAyane, OzawaSayaka, TaguchiMasato
Original Abstract of the Article :
We encountered cases in which the anticoagulant effects of warfarin (CYP2C9 substrate) were reversibly attenuated by the concomitant administration of rifampicin or bosentan, which are potent pregnane X receptor (PXR) ligands. The purpose of the present study is to report the previous case with rifa...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1248/bpb.b21-00853
データ提供:米国国立医学図書館(NLM)
Warfarin and PXR Ligand Drugs: Unexpected Interactions in the Desert of Medications
The world of medications is a bustling marketplace, with a vast array of drugs interacting in complex ways. This research delves into the intriguing interaction between warfarin, a common blood thinner, and PXR ligand drugs, a class of medications that activate the pregnane X receptor (PXR). It's like exploring a hidden oasis in the desert of medications, where unexpected interactions can influence drug efficacy.
The study highlights the importance of monitoring drug interactions, especially when combining warfarin with PXR ligand drugs like rifampicin or bosentan. It's like navigating a treacherous desert path, where unexpected sandstorms can disrupt the journey.
The Importance of Careful Monitoring
The study found that PXR ligand drugs can significantly reduce the anticoagulant effects of warfarin, potentially increasing the risk of blood clots. It's like discovering a hidden pitfall in the desert of medications, a reminder that understanding drug interactions is critical for safe and effective treatment.
Navigating the Desert of Medications
This research emphasizes the importance of open communication between patients and healthcare providers about all medications they are taking. It's like sharing a map with a trusted guide, ensuring a safe and effective journey through the desert of medications.
Dr. Camel's Conclusion
This study is a reminder that the desert of medications is a complex and dynamic environment. It's a call for vigilance and collaboration, ensuring that patients receive the safest and most effective treatment possible.
Date :
- Date Completed 2022-06-03
- Date Revised 2022-06-03
Further Info :
Related Literature
English
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