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Thalidomide and discoid lupus erythematosus: case series and review of literature.

Author: AltomonteMaria, CuzzolaMaria, MalaraGiovanna, PolitiCristina, TrifiròCaterina, TripepiGiovanni, VerduciChiara

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Thalidomide is an off-label anti-inflammatory drug for severe, refractory dermatologic conditions. While effective, it carries neurotoxic and teratogenic risks, limiting its use to only the most serious cases.
Paper Details　
Original Abstract of the Article :
The anti-inflammatory drug, thalidomide, is often administered off-label especially in dermatology patients with diseases refractory to different medications. The drug's mechanism of action is not well understood but clinical evidence suggests an immunomodulatory function. Although this drug is a us...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932252/

データ提供：米国国立医学図書館（NLM）

Thalidomide's Role in Discoid Lupus Erythematosus: A Case Series and Literature Review

This study, conducted in the field of dermatology, examines the use of thalidomide in patients with discoid lupus erythematosus (DLE), a chronic inflammatory skin condition. It's like exploring a desert where traditional remedies are no longer enough, and new solutions are needed. The study uses a case series approach and literature review to explore the potential benefits and risks of thalidomide. The researchers discuss the drug's mechanism of action, its efficacy in treating DLE, and its associated neurotoxic and teratogenic side effects.

Navigating the Risks and Benefits of Thalidomide

The study provides valuable insights into the therapeutic landscape of DLE. It's like having a map with both lush oases and treacherous sandstorms, where navigating the risks and benefits is key. The authors acknowledge the potential of thalidomide in treating DLE but emphasize the need for careful monitoring and reserved use only in severe and refractory cases.

Treating DLE: A Desert of Challenges

DLE can be a challenging condition to manage. It's like traversing a desert with unpredictable weather patterns and scarce resources. While thalidomide offers potential therapeutic value, it's important to understand the risks and be mindful of the potential side effects.

Dr. Camel's Conclusion

This study highlights the need for a careful balance between the potential benefits and risks of thalidomide in treating DLE. While it's a valuable tool in certain cases, it's essential to weigh its efficacy against its potential adverse effects and to use it judiciously.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-05
Further Info :

Pubmed ID

35371272

DOI: Digital Object Identifier

PMC8932252

Related Literature

Article Analysis
・Side Effects of thalidomide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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