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Case study: New onset of neuropsychiatric symptoms following switching to a dolutegravir regimen.

Author: BadatAhmed, LowtonKarishma

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Dolutegravir is a commonly used antiretroviral medication for HIV, but it can have neuropsychiatric side effects. One patient experienced significant physical injuries after developing new onset neuropsychiatric symptoms secondary to dolutegravir. The patient's symptoms resolved after switching back to an efavirenz regimen. This case highlights the importance of monitoring for neuropsychiatric side effects with dolutegravir.
Paper Details　
Original Abstract of the Article :
Although reports of neuropsychiatric side effects have been reported with efavirenz, these have been limited in comparison with regard to the now recommended dolutegravir regimens. We present a patient with new onset neuropsychiatric manifestations secondary to dolutegravir that resulted in signific...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991107/

データ提供：米国国立医学図書館（NLM）

Dolutegravir: A New Antiretroviral with Potential Neuropsychiatric Side Effects

Antiretroviral therapy (ART) has revolutionized the treatment of HIV infection, but it can sometimes be associated with side effects. This case study explores the emergence of neuropsychiatric symptoms in a patient who switched from an efavirenz-based ART regimen to a dolutegravir-based regimen. The study highlights the importance of vigilance for potential side effects when initiating or switching ART regimens.

Navigating the Side Effects of ART

This case study underscores the importance of monitoring for neuropsychiatric side effects when initiating or switching ART regimens. The patient's experience highlights the need for close follow-up and careful management of potential adverse events related to ART.

A Call for Vigilance

This case study serves as a reminder that even with advances in ART, vigilance is essential for managing potential side effects. Healthcare providers should be aware of the potential for neuropsychiatric complications associated with dolutegravir and other ART medications, and they should monitor patients closely for any changes in mental health.

Dr.Camel's Conclusion

The desert of HIV treatment is vast and complex, with constant changes in the landscape of available therapies. This case study highlights the importance of being aware of the potential side effects of new medications, like dolutegravir. By being vigilant and attentive, we can ensure that patients receive the best possible care and navigate the challenges of HIV treatment with safety and success.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-13
Further Info :

Pubmed ID

35402013

DOI: Digital Object Identifier

PMC8991107

Related Literature

Article Analysis
・Side Effects of efavirenz
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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