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Health-Related Quality of Life and Side Effects in Gastrointestinal Stromal Tumor (GIST) Patients Treated with Tyrosine Kinase Inhibitors: A Systematic Review of the Literature.

Author: ElieMai, FumagalliElena, HussonOlga, JonesRobin L, Le CesneAxel, MarquinaGloria, SteeghsNeeltje, den HollanderDide, van de WalDeborah, van der GraafWinette T A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of gastrointestinal stromal tumors (GISTs) and have significantly improved overall survival. However, TKIs can also have side effects. This review summarizes the available literature on health-related quality of life (HRQoL) issues and side effects of different TKIs used to treat GIST.
Paper Details　
Original Abstract of the Article :
The introduction of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of gastrointestinal stromal tumors (GISTs), resulting in a substantial gain in median overall survival. Subsequently, health-related quality of life (HRQoL) has become more relevant. Here, we systematically review...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997462/

データ提供：米国国立医学図書館（NLM）

Quality of Life and Side Effects in GIST Patients: A Systematic Review of TKIs

The field of [oncology] has witnessed significant progress in the treatment of [gastrointestinal stromal tumors (GISTs)] with the advent of [tyrosine kinase inhibitors (TKIs)]. While these drugs have revolutionized [treatment outcomes] and improved [survival rates], the impact on [health-related quality of life (HRQoL)] and [side effects] remain a crucial concern. This systematic review examines the existing literature to provide a comprehensive overview of [HRQoL] issues and [side effects] associated with different [TKIs] used in [GIST] treatment.

Navigating the Impact of TKIs on GIST Patients' Quality of Life

This systematic review provides a valuable overview of the [HRQoL] issues and [side effects] associated with [TKIs] in [GIST] treatment. The findings highlight the importance of considering both the benefits and potential drawbacks of [TKIs] in optimizing [treatment decisions] for [GIST] patients. This review underscores the need for ongoing research to develop novel [TKIs] with improved [safety profiles] and [efficacy] to further enhance the quality of life for [GIST] patients.

GIST Treatment: Balancing Benefits and Side Effects

This systematic review, like a compass guiding us through the challenging terrain of [GIST] treatment, provides valuable insights into the complex interplay between [TKIs], [HRQoL], and [side effects]. The review highlights the need for a balanced approach, weighing the potential benefits of [TKIs] against the potential [side effects] to optimize [treatment decisions]. This research underscores the importance of personalized medicine and the continued search for novel [TKIs] with improved [safety profiles] to enhance the lives of [GIST] patients.

Dr. Camel's Conclusion

This comprehensive review, like a map revealing hidden pathways in the desert of [GIST] treatment, underscores the importance of considering both the benefits and side effects of [TKIs]. The review highlights the need for ongoing research to develop novel [TKIs] with improved [safety profiles] and [efficacy] to improve the quality of life for [GIST] patients. By understanding the complexities of [GIST] treatment, we can strive to provide personalized care that balances the benefits and risks of these life-saving medications.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-15
Further Info :

Pubmed ID

35406604

DOI: Digital Object Identifier

PMC8997462

SNS
PICO Info
in preparation
Languages

English

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