Cardiotoxicity of BTK inhibitors: ibrutinib and beyond.

Author: AwanFarrukh T, ChristensenBradley W, ZahaVlad G

Paper Details 
Original Abstract of the Article :
INTRODUCTION: The development of Bruton<apos;>s Tyrosine Kinase (BTK) inhibitors has transformed the treatment of B-cell malignancies and other non-malignant conditions. Management of the unique cardiotoxic profile of these agents requires prompt recognition and a multi-disciplinary approach. AREAS...See full text at original site
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引用元:
https://doi.org/10.1080/17474086.2022.2067526

データ提供:米国国立医学図書館(NLM)

Navigating the Arid Landscape of BTK Inhibitor Cardiotoxicity: A Guide for Clinicians

This research explores the challenging terrain of cardiotoxicity associated with Bruton's Tyrosine Kinase (BTK) inhibitors, a class of medications that have revolutionized treatment for B-cell malignancies and other conditions. The study provides a comprehensive review of the potential cardiac side effects associated with these agents, emphasizing the importance of prompt recognition and a multi-disciplinary approach to managing these risks.

Aridity and Uncertainty: The Cardiotoxicity of BTK Inhibitors

This research highlights the complexities associated with BTK inhibitors, a class of medications that have shown promise in treating various conditions but are also associated with potential cardiac side effects. The study's findings indicate that these medications can cause a range of cardiac adverse events, including atrial fibrillation, hypertension, and ventricular arrhythmias. This underscores the need for careful monitoring and management of these potential risks.

Navigating the Desert of BTK Inhibitor Cardiotoxicity: A Multi-Disciplinary Approach

The study emphasizes the importance of a multi-disciplinary approach to managing the cardiotoxicity associated with BTK inhibitors. It highlights the need for prompt recognition of these potential side effects and for close collaboration between cardiologists, hematologists, and other healthcare professionals to optimize patient care. The study also emphasizes the importance of early detection and intervention to minimize the potential for serious cardiac complications.

Dr. Camel's Conclusion

This research provides a valuable roadmap for navigating the challenging terrain of BTK inhibitor cardiotoxicity. The study's findings highlight the importance of a multi-disciplinary approach, early detection, and close monitoring to effectively manage these potential risks. It underscores the importance of ongoing research and development of newer BTK inhibitors with more favorable toxicity profiles, striving to create a more fertile landscape for patients receiving these treatments.

Date :
  1. Date Completed 2022-05-17
  2. Date Revised 2022-06-01
Further Info :

Pubmed ID

35437106

DOI: Digital Object Identifier

10.1080/17474086.2022.2067526

Related Literature

SNS
PICO Info
in preparation
Languages

English

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