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Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents.
Author: AljohaniFaizah S, AouadMohamed R, BardaweelSanaa K, ElwakilBassma H, HagarMohamed, HagrasNancy Abd-Elkader, Hussein MogahedNermine Mogahed Fawzy, RezkiNadjet, ShetaEman
Original Abstract of the Article :
<i>Toxoplasma gondii</i> (<i>T. gondii</i>) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects. Focused sulfonamide-1,2,3-triazole hybrids <b>3a-c</b> were wisely designed and synthesized via copper catalyzed 1,3-dipolar cycloaddit...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025934/
データ提供:米国国立医学図書館(NLM)
Fighting Toxoplasmosis: A Camel's Perspective on Novel Sulfonamide-1,2,3-triazole Molecular Conjugates
This research explores the potential of [novel sulfonamide-1,2,3-triazole molecular conjugates] as [antiparasitic agents] against [Toxoplasma gondii]. The researchers synthesized these compounds using a [copper-catalyzed 1,3-dipolar cycloaddition approach] and loaded them onto [chitosan nanoparticles] to enhance their efficacy. They found that these nanoformulations demonstrated promising results in [experimentally infected mice] with [toxoplasmosis], leading to [100% survival] and [100% parasite reduction].
A Camel's Journey: Tackling Toxoplasmosis with Nanoformulations
This study provides hope for the development of new and effective treatments for [toxoplasmosis]. The use of [nanoformulations] to deliver these compounds effectively is a significant advancement in [antiparasitic drug development].
Navigating the Desert of Toxoplasmosis: A Camel's Advice
The study's findings offer a glimmer of hope for individuals dealing with [toxoplasmosis]. However, it's important to remember that further research is needed to fully understand the long-term effects of these compounds and to develop safe and effective clinical treatments.
Dr.Camel's Conclusion
This study explores the potential of novel sulfonamide-1,2,3-triazole molecular conjugates as potent antiparasitic agents against Toxoplasma gondii. The researchers developed chitosan nanoparticle-based nanoformulations that demonstrated promising results in experimentally infected mice, leading to 100% survival and 100% parasite reduction.
Date :
- Date Completed 2022-04-26
- Date Revised 2022-07-16
Further Info :
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