Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2.

Author: AljabaliAlaa A A, ChellappanDinesh Kumar, ChenRuei-Ming, DuaKamal, El-TananiMohamed, GuptaGaurav, KamalakannanSiva, KrishnanAnand, MishraVijay, Serrano-ArocaÁngel, ShitutAnushka, SinghSachin Kumar, TambuwalaMurtaza M, VadivalaganChithravel

Paper Details 
Original Abstract of the Article :
Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic posi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022400/

データ提供:米国国立医学図書館(NLM)

Artificial MicroRNAs: A New Weapon Against COVID-19?

The world of medicine is constantly searching for innovative ways to combat infectious diseases like COVID-19. This study delves into the fascinating world of exosomes, tiny cellular packages that act as messengers, carrying important information between cells. The researchers investigated the potential of using artificial microRNAs (amiRNAs), delivered through exosomes, to target the RNA genes responsible for the COVID-19 virus's transcription. This approach could be a game-changer in the fight against this persistent foe.

Targeting the Virus's RNA: A New Strategy

The study suggests that amiRNAs could be a powerful tool for inhibiting the replication of the COVID-19 virus. AmiRNAs are designed to specifically target the virus's RNA, essentially silencing its ability to create new viral particles. By delivering these amiRNAs through exosomes, the researchers aim to directly target infected cells and suppress the virus's activity.

Harnessing the Power of Exosomes

Exosomes are like tiny boats, navigating the vast ocean of our bodies, delivering valuable cargo from one cell to another. This study highlights their potential as carriers for amiRNAs, effectively transporting these molecular weapons directly to the battleground of infection. It's like sending a fleet of miniature delivery drones, armed with anti-viral agents, to combat the virus at its source.

Dr.Camel's Conclusion

This study opens a new avenue for the development of targeted therapies against COVID-19. It's like finding a hidden oasis in the vast desert of viral research. By utilizing the natural delivery system of exosomes and the targeted nature of amiRNAs, scientists may be able to develop more effective treatments and potentially pave the way for a new era in antiviral therapy.

Date :
  1. Date Completed 2022-06-02
  2. Date Revised 2022-12-21
Further Info :

Pubmed ID

35461900

DOI: Digital Object Identifier

PMC9022400

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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