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Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique.
Author: Abou-OmarMona N, AminMohammed A, AnnadiAbdelaziz M, AttiaMohamed S, El ZaharNoha M, MohamedEkram H, YoussefAhmed O
Original Abstract of the Article :
A rapid and selective LC-MS/MS method is described for the simultaneous assay of Avanafil and Dapoxetine in human plasma <i>via</i> a protein precipitation (PP) sample preparation technique. Tadalafil was chosen as the internal standard reaching good recovery and reproducibility while diminishing th...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040755/
データ提供:米国国立医学図書館(NLM)
A New Oasis in the Desert of Erectile Dysfunction Treatment
Erectile dysfunction (ED) can be a challenging condition, often leading to a search for effective treatment options. This study explores a new analytical method for simultaneously measuring two medications, Avanafil and Dapoxetine, in human plasma. The researchers developed a rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying these drugs, which are used to treat ED and premature ejaculation, respectively. This method provides a more precise and efficient way to monitor drug levels in patients undergoing treatment.
Precise Measurement for Enhanced Treatment
This study offers a significant improvement in the analysis of Avanafil and Dapoxetine in human plasma. The developed LC-MS/MS method is more rapid, selective, and accurate than previous methods, providing a more robust tool for monitoring drug levels and optimizing treatment regimens.
Navigating the Desert of ED Treatment
This research highlights the ongoing quest for better and more precise methods to manage ED and premature ejaculation. The development of this analytical method could contribute to a more individualized and effective approach to treatment.
Dr. Camel's Conclusion
This study, like a skilled navigator charting a course through the desert of ED treatment, introduces a new and precise tool for monitoring drug levels. This method offers a promising path towards more effective and personalized treatment strategies, bringing a glimmer of hope to the desert of ED management.
Date :
- Date Completed n.d.
- Date Revised 2022-07-16
Further Info :
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