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A controlled study of concurrent therapy with a nonacetylated salicylate and naproxen in rheumatoid arthritis.

Author: BlockaK, CassellS, FurstD E, HarrisE R, HirschbergJ M, JosephsonN, LachenbruchP A, PaulusH E, TrimbleR B

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A combination of choline magnesium trisalicylate and naproxen was not significantly more effective than either drug alone in treating rheumatoid arthritis. However, the combination was associated with a higher incidence of side effects.
Paper Details　
Original Abstract of the Article :
Previous studies of combinations of nonsteroidal drugs used in the treatment of rheumatoid arthritis (RA) have yielded conflicting results. We used standard methods to measure disease activity and high pressure liquid chromatography to measure plasma drug concentrations. We used doses of choline mag...See full text at original site
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引用元：
https://doi.org/10.1002/art.1780300204

データ提供：米国国立医学図書館（NLM）

Rheumatoid Arthritis: Exploring Synergistic Therapies

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, stiffness, and swelling in the joints. This study investigates the potential benefits of combining two nonsteroidal anti-inflammatory drugs (NSAIDs), choline magnesium trisalicylate (CMT) and naproxen, for the treatment of RA.

The study compared the effectiveness and toxicity of different combinations of CMT and naproxen in a group of RA patients. The results suggest that combining CMT and naproxen may offer some benefits over either medication alone, but the difference was not significant enough to be considered clinically relevant.

Combination Therapies: Exploring New Avenues for RA Treatment

This study highlights the complexity of finding effective treatments for RA. The results suggest that while combining NSAIDs may not always lead to significantly better outcomes, it remains an area of active research. There may be specific patient groups or situations where combination therapies might offer a more significant advantage.

RA Treatment: A Collaborative Journey

Managing RA requires a collaborative approach between patients and healthcare providers. This study emphasizes the importance of considering individual patient needs and finding the right treatment strategy for each person. It's like navigating a vast desert, exploring different paths and finding the one that leads to optimal health and well-being.

Dr. Camel's Conclusion

This study reminds us that the journey of managing RA can be challenging, like navigating a scorching desert filled with unexpected obstacles. Finding the right treatment approach is crucial for achieving optimal health outcomes. This study suggests that while combination therapies may offer some benefits, the search for the most effective strategies for managing RA continues.

Date :
  1. Date Completed 1987-04-06
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

3548732

DOI: Digital Object Identifier

10.1002/art.1780300204

Related Literature

Article Analysis
・Effects of choline magnesium trisalicylate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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