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Mitogen-activated protein kinase inhibitor-associated retinopathy (MEKAR). A clinical case.

Author: Badillo ArconesE, Buenasmañanas-MaesoM, Gutiérrez-MonteroÓ, Monja-AlarcónN, Reche-SainzJ A, Toledano-FernándezN

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This case report describes a 55-year-old woman who developed bilateral neurosensory detachments and blurred vision while on a MEK inhibitor for metastatic melanoma. This retinopathy, known as MEKAR, resolved upon discontinuation of the treatment.
Paper Details　
Original Abstract of the Article :
Mitogen-activated protein kinase kinase (MEK) inhibitors have significantly improved the prognosis of various types of cancer such as metastatic melanoma. However, their use is usually associated with ocular side effects. A retinopathy associated with these agents (MEKAR) has been described, consist...See full text at original site
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引用元：
https://doi.org/10.1016/j.oftale.2022.02.006

データ提供：米国国立医学図書館（NLM）

Mitogen-Activated Protein Kinase Inhibitor-Associated Retinopathy (MEKAR): A Clinical Case

Mitogen-activated protein kinase kinase (MEK) inhibitors are a valuable addition to the [treatment of various cancers]. However, [ocular side effects] are a concern. This case report describes a [retinal complication associated with MEK inhibitors: MEKAR]. The authors present a case of a 55-year-old woman who developed [bilateral neurosensory detachments] after taking a MEK inhibitor. This case highlights the importance of [monitoring patients closely for ocular side effects] during MEK inhibitor therapy.

A Case of MEKAR: A Reminder of Potential Side Effects

This case report is a stark reminder that [even promising new cancer treatments can have unexpected side effects]. The authors' observation of [MEKAR in a patient taking a MEK inhibitor] underlines the importance of being vigilant in identifying and managing these potential complications.

Managing the Risks of MEK Inhibitors

Patients taking MEK inhibitors should [be aware of the potential for ocular side effects]. They should [report any changes in vision] to their doctor immediately. Early detection and management of MEKAR can help preserve vision and improve patient outcomes.

Dr.Camel's Conclusion

This study, like a desert traveler encountering a sudden sandstorm, reminds us that even the most beneficial treatments can have unforeseen consequences. The case of MEKAR highlights the importance of careful monitoring and prompt intervention when faced with potential complications. It's a reminder that we must remain vigilant and adaptable in our approach to patient care.

Date :
  1. Date Completed 2022-05-10
  2. Date Revised 2022-05-10
Further Info :

Pubmed ID

35526952

DOI: Digital Object Identifier

10.1016/j.oftale.2022.02.006

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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