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ZIF-8 nanoparticles coated with macrophage-derived microvesicles for sustained, targeted delivery of dexamethasone to arthritic joints.

Author: JiaMing, LeiFenting, LiChunhong, LiuYan, NiuHong, WangChenglong, WangYao, ZhangDan, ZhengXiu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dexamethasone sodium phosphate (Dex) encapsulated in zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, camouflaged with macrophage-derived microvesicles (MV), formed a biomimetic drug delivery system (MV/Dex/ZIF-8). This nanosystem demonstrated high drug loading, encapsulation efficiency, stability, and prolonged circulation time, enabling sustained release of Dex in inflamed joint tissues. The study suggests this camouflaged drug carrier as a potential approach for targeted and sustained delivery of Dex in rheumatoid arthritis treatment.
Paper Details　
Original Abstract of the Article :
Dexamethasone sodium phosphate (Dex) is widely used in the clinic for the treatment of rheumatoid arthritis. However, it circulates in the blood for a short time and it is linked to a high risk of severe side effects caused by repeated dosing. Here, we encapsulated Dex onto zeolitic imidazolate fram...See full text at original site
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引用元：
https://doi.org/10.1080/1061186X.2022.2077949

データ提供：米国国立医学図書館（NLM）

Delivering Dexamethasone with Precision: A Novel Approach to Arthritis Treatment

Rheumatoid arthritis, like a relentless sandstorm, can cause inflammation, pain, and stiffness in the joints. Dexamethasone, a powerful anti-inflammatory drug, is commonly used to treat arthritis, but it can have significant side effects due to its systemic distribution. In this study, researchers developed a novel drug delivery system to target dexamethasone directly to arthritic joints.

A Smart Delivery System

The researchers encapsulated dexamethasone into ZIF-8 nanoparticles, a type of metal-organic framework. To enhance the nanoparticles' ability to reach the target site, they coated them with macrophage-derived microvesicles (MVs), effectively creating a biomimetic delivery system. Imagine this as a desert caravan with a built-in GPS system, navigating its way to a specific oasis.

A New Paradigm in Arthritis Treatment

This research offers a promising new approach to arthritis treatment, potentially minimizing side effects while maximizing therapeutic efficacy. By delivering dexamethasone directly to the inflamed joints, this targeted approach could help patients manage their symptoms more effectively.

Dr. Camel's Conclusion

This study, like a well-equipped caravan traversing the desert of arthritis treatment, demonstrates the power of targeted drug delivery. By using biomimetic nanoparticles, this innovative approach holds great potential for improving the lives of patients with rheumatoid arthritis.

Date :
  1. Date Completed 2022-10-05
  2. Date Revised 2022-12-22
Further Info :

Pubmed ID

35549591

DOI: Digital Object Identifier

10.1080/1061186X.2022.2077949

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SNS
PICO Info
in preparation
Languages

English

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