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Original Abstract of the Article :
Approval of the first boronic acid group-containing drug, bortezomib, in 2003 for the treatment of multiple myeloma sparked an increased interest of medicinal chemists in boronic acidbased therapeutics. As a result, another boronic acid moiety-harboring medication, ixazomib, was approved in 2015 as ...See full text at original site
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引用元：
https://doi.org/10.2174/1568009622666220516102235
データ提供：米国国立医学図書館（NLM）
Dietary Flavonoids and Boronic Acid-Based Drugs: A Complex Interplay
The world of [drug development] is a complex landscape, with a constant search for new and effective therapies. This research delves into the intriguing interaction between dietary flavonoids and boronic acid-based drugs, exploring a potential pitfall in the desert of drug development. The authors highlight the potential antagonism between catechol-containing flavonoids and boronic acid-based drugs, raising concerns about the efficacy of these promising therapies.
A Potential Trap in the Desert: Flavonoid-Drug Interactions
The study reveals that catechol-containing flavonoids, such as those found in green tea and other common dietary sources, can interact with boronic acid-based drugs, including the widely used multiple myeloma treatment bortezomib. This interaction can lead to the formation of stable cyclic boronate esters, effectively rendering the drugs inactive. This is like discovering a hidden trap in the desert, potentially hindering our progress towards effective treatments.
Navigating the Desert of Drug Development: Avoiding Potential Pitfalls
This research emphasizes the importance of considering dietary factors when developing and administering boronic acid-based drugs. The authors call for further research to clarify the potential interactions with various dietary flavonoids, ensuring optimal therapeutic outcomes for patients. This is like carefully mapping the desert, identifying and avoiding potential hazards to ensure a safe and successful journey.
Dr. Camel's Conclusion
This research highlights the importance of considering the complex interplay between dietary factors and drug efficacy. The study underscores the need for continued research to fully understand the potential interactions between dietary flavonoids and boronic acid-based drugs. As we continue to explore the vast desert of drug development, it's crucial to be mindful of potential pitfalls and strive for a safe and effective path to healing.
Date :
- Date Completed 2022-09-08
- Date Revised 2022-09-21
Further Info :
Related Literature
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