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Optimization of rifampicin encapsulation in PLGA polymeric reservoirs.

Author: Castañeda-FernandezCarolina, Chávez-SantosRosa María, Espitia-PinzónClara, KozinaAnna, MartínezRoberto, Silva-MirandaMayra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the challenges involved in encapsulating rifampicin, a tuberculosis antibiotic, within polymeric reservoirs. The authors found that low encapsulation efficiency was due to the drug's solubility in the aqueous medium during particle solidification. They identified ways to improve drug loading, such as increasing polymer concentration, solvent evaporation rate, and particle size. Multiple emulsions, especially double w/o/w emulsions, could further improve encapsulation, but this resulted in larger and more porous particles.
Paper Details　
Original Abstract of the Article :
Rifampicin is one of the most commonly used antibiotics for treating tuberculosis, but shows low bioavailability and requires long-term administration, and hence its use may result in severe side effects. Encapsulation of rifampicin in polymeric reservoirs allows it to be administered locally and im...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2022.121844

データ提供：米国国立医学図書館（NLM）

Optimizing Rifampicin Delivery: A Tale of Encapsulation

Tuberculosis (TB), a disease caused by bacteria, remains a major global health threat. Rifampicin, a powerful antibiotic, is widely used in TB treatment. However, rifampicin has low bioavailability, meaning it's not easily absorbed by the body. This can lead to long-term administration and a higher risk of side effects. This research, a deep dive into the world of drug encapsulation, aims to improve the delivery of rifampicin by encapsulating it in polymeric reservoirs. The researchers systematically investigated various parameters to enhance the encapsulation efficiency of rifampicin, aiming to improve its effectiveness while minimizing the risk of side effects.

The Verdict: Encapsulation Holds the Key

The research reveals that encapsulation of rifampicin in polymeric reservoirs can significantly improve its loading levels. This is crucial for achieving adequate therapeutic effects. The key to success lies in optimizing the fabrication conditions, such as increasing the polymer concentration, solvent evaporation rate, and particle size. This helps to prevent the loss of rifampicin during the encapsulation process. The researchers also identified the particle solidification stage as a critical step, where a significant amount of rifampicin is lost.

A Smoother Journey for Rifampicin: Implications for TB Treatment

These findings are a major step towards improving the treatment of TB. By improving the delivery of rifampicin, this research could lead to a more effective and safer treatment, potentially reducing the duration of therapy and minimizing the risk of side effects. It's a journey towards a healthier future for people living with TB.

Dr. Camel's Conclusion

Encapsulation, like a camel storing water in its hump for a long journey, can help rifampicin travel through the body more efficiently. This research paves the way for a more effective and safer treatment for TB, offering hope for a healthier future for patients.

Date :
  1. Date Completed 2022-06-21
  2. Date Revised 2022-06-21
Further Info :

Pubmed ID

35605890

DOI: Digital Object Identifier

10.1016/j.ijpharm.2022.121844

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Languages

English

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