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Impact of Atorvastatin on Skeletal Muscle Mitochondrial Activity, Locomotion and Axonal Excitability-Evidence from <i>ApoE<sup>-/-</sup></i> Mice.

Author: BonalumeVeronica, CorsiniAlberto, GrecoMaria Francesca, MacchiChiara, MagnaghiValerio, MelfiValentina, MozzoMarta, RuscicaMassimiliano, SirtoriCesare R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

High-dose atorvastatin was evaluated for its impact on skeletal muscle mitochondrial activity, exercise capacity, and axonal excitability in a mouse model of atherosclerosis. Findings revealed reduced mitochondrial biogenesis and ATP production, mild motor impairment, and altered responsiveness of mechanoceptive and nociceptive fibers. These findings highlight potential mechanisms contributing to statin-associated muscle pain and emphasize the importance of understanding these mechanisms for improving patient adherence.
Paper Details　
Original Abstract of the Article :
The cardiovascular benefit of statins is well established. However, only 20% of high-risk patients remain adequately adherent after 5 years of treatment. Among reasons for discontinuation, statin associated-muscle pain symptoms are the most prevalent. Aim of the present study was to evaluate the imp...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141374/

データ提供：米国国立医学図書館（NLM）

Atorvastatin: Navigating the Desert of Side Effects

This research delves into the complex landscape of statin therapy, exploring the impact of atorvastatin on skeletal muscle mitochondrial activity, locomotion, and axonal excitability. The authors utilize a murine model of atherosclerosis to investigate the potential side effects of high-dose atorvastatin.

A Camel's Perspective on Side Effects

Imagine a camel traversing a scorching desert, facing the challenges of reduced energy levels and altered muscle function. This research reveals that high-dose atorvastatin might similarly impact skeletal muscle, potentially leading to reduced mitochondrial activity and altered motor function.

Dr. Camel's Conclusion

This research suggests that high-dose atorvastatin might have unintended effects on skeletal muscle, highlighting the need for careful monitoring and individualized treatment approaches. The desert of statin therapy requires careful navigation, considering individual needs and potential side effects to ensure optimal outcomes.

Date :
  1. Date Completed 2022-05-31
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

35628225

DOI: Digital Object Identifier

PMC9141374

Related Literature

Article Analysis
・Side Effects of atorvastatin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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