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Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study.

Author: CarrazanaEnrique, DesaiJay, DlugosDennis, RabinowiczAdrian L, TarquinioDaniel, WhelessJames W

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Diazepam nasal spray demonstrated a consistent safety profile across age subgroups in patients with seizure clusters.
Paper Details　
Original Abstract of the Article :
BACKGROUND: To evaluate safety and tolerability of long-term treatment with diazepam nasal spray (Valtoco) for seizure clusters in patients aged six to 17 years. METHODS: The study enrolled patients aged six to 65 years with frequent seizure clusters. Age- and weight-based doses of diazepam nasal s...See full text at original site
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引用元：
https://doi.org/10.1016/j.pediatrneurol.2022.04.011

データ提供：米国国立医学図書館（NLM）

Diazepam Nasal Spray: A Safe Haven for Children with Epilepsy

Epilepsy is a neurological condition that can be a real challenge, especially for children and adolescents. Seizures can be unpredictable, and finding effective and safe treatment options is crucial. This study delves into the safety of diazepam nasal spray for the management of seizure clusters in young patients.

The research involved a long-term study of patients aged six to 17 years who experienced frequent seizure clusters. The researchers evaluated the safety and tolerability of diazepam nasal spray, a common treatment option. The study also investigated the impact of age and weight on the dosage and frequency of administration.

The study found that diazepam nasal spray was safe and well-tolerated across different age groups, with no serious adverse events related to treatment. The researchers determined that dosing guidelines based on age and weight are safe and effective.

A Beacon of Hope for Families Battling Epilepsy

This research brings a sense of relief to families grappling with epilepsy. It offers a safe and effective treatment option for children and adolescents, helping them manage their condition and live a more fulfilling life. The findings suggest that diazepam nasal spray can be a valuable tool in the arsenal of treatments for this complex disorder.

Navigating Epilepsy Treatment with Confidence

The study provides evidence-based guidance for managing epilepsy in children and adolescents. It highlights the importance of individualizing treatment based on age and weight, ensuring the safety and effectiveness of the medication. It's like navigating a desert oasis – finding the right source of water and nourishment for a healthy journey.

Dr.Camel's Conclusion

This study provides valuable information for healthcare professionals and families dealing with epilepsy. It demonstrates that diazepam nasal spray can be a safe and effective treatment option for young patients, offering a sense of hope and reassurance.

Date :
  1. Date Completed 2022-06-21
  2. Date Revised 2022-07-26
Further Info :

Pubmed ID

35636283

DOI: Digital Object Identifier

10.1016/j.pediatrneurol.2022.04.011

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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