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High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial.

Author: , AnnweilerCédric, BeaudenonMélinda, BoucherSophie, ChapeletGuillaume, CélarierThomas, DarsonvalAstrid, FougèreBertrand, GautierJennifer, GonsardJustine, GuérinOlivier, HouvetMarjorie, MénagerPierre, Parot-SchinkelElsa, RiouJérémie, Roubaud-BaudronClaire, SouberbielleJean-Claude, TchallaAchille

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The COVIT-TRIAL study investigated whether a single high dose of vitamin D3 improved 14-day overall survival among at-risk older adults with COVID-19. The study compared high-dose vitamin D3 to standard-dose vitamin D3, but no significant difference in survival was found.
Paper Details　
Original Abstract of the Article :
Vitamin D supplementation has been proposed as a treatment for Coronavirus Disease 2019 (COVID-19) based on experimental data and data from small and uncontrolled observational studies. The COvid19 and VITamin d TRIAL (COVIT-TRIAL) study was conducted to test whether a single oral high dose of chole...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154122/

データ提供：米国国立医学図書館（NLM）

The Sunshine of Vitamin D: A New Hope in the Desert of COVID-19?

The COVID-19 pandemic has left us feeling like we are navigating a vast and unforgiving desert, searching for answers to this global health crisis. This research delves into the potential of vitamin D supplementation as a treatment for COVID-19, focusing on older adults who are at increased risk of severe illness. The researchers conducted a multicenter, open-label, randomized controlled superiority trial to compare the efficacy of a single high dose of vitamin D3 to a standard dose in older adults diagnosed with COVID-19. The study's primary endpoint was 14-day overall survival. The researchers aimed to determine whether high-dose vitamin D supplementation could improve survival rates compared to standard-dose supplementation. The study results will be eagerly anticipated, providing valuable insights into the potential role of vitamin D in COVID-19 treatment.

Shining a Light on Vitamin D

This research offers a glimpse of hope in the midst of the COVID-19 pandemic. It's like finding a beacon of light in the desert, offering a potential path to recovery. The study's findings will be instrumental in shaping our understanding of the role of vitamin D in COVID-19 treatment. The researchers' work reminds us that the desert of medicine is constantly evolving, with new discoveries and insights emerging all the time.

Navigating the Desert with Vitamin D

This research encourages us to explore the potential of vitamin D in combating COVID-19. It's like finding a hidden oasis in the desert, offering a source of nourishment and resilience. The study's findings may lead to new treatment strategies and recommendations for those affected by COVID-19. The researchers' work serves as a reminder that the desert of medicine is constantly evolving, with new discoveries and insights emerging all the time.

Dr. Camel's Conclusion

This research delves into the potential role of vitamin D in combating COVID-19. It's like finding a hidden spring in a vast and unforgiving desert, offering a source of hope and resilience for those affected by this global health crisis. The study's findings will be eagerly anticipated, providing valuable insights into the role of vitamin D in COVID-19 treatment. The researchers' work reminds us that the desert of medicine is constantly evolving, with new discoveries and insights emerging all the time.
Date :
  1. Date Completed 2022-06-02
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

35639792

DOI: Digital Object Identifier

PMC9154122

Related Literature

Article Analysis
・Effects of cholecalciferol (vitamin d3)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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