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Effects of pimavanserin and lorcaserin on alcohol self-administration and reinstatement in male and female rats.

Author: FletcherPaul J, FunkDouglas, HigginsGuy A, JiXiaodong, LiZhaoxia, LêA D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of manipulating serotonin (5-HT) receptors on alcohol self-administration and alcohol-seeking behavior in rats. The results suggest that blocking 5-HT2A receptors has limited effects on alcohol-seeking, while activating 5-HT2C receptors reduces alcohol self-administration, drinking, and seeking, potentially by blunting the effect of alcohol on mesolimbic dopamine release.
Paper Details　
Original Abstract of the Article :
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) modulates fundamental motivational processes, and the neurochemical and behavioural effects of drugs of abuse. Recently, attention has focused on the role of 5-HT acting via 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptor sub-types in this ...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuropharm.2022.109150

データ提供：米国国立医学図書館（NLM）

Taming the Beast: Exploring New Strategies to Curb Alcohol Addiction

Alcohol addiction, a treacherous desert of cravings and relapse, is a complex and challenging condition. This research explores the role of serotonin, a neurotransmitter known for its influence on mood and behavior, in alcohol addiction. The study focuses on the impact of manipulating serotonin receptors, specifically the 5-HT2A and 5-HT2C subtypes, on alcohol self-administration and alcohol-seeking behavior in rats. The researchers, like skilled desert explorers, sought to understand how these receptors contribute to the complex cycle of addiction.

Serotonin: A Guiding Star in the Desert of Addiction

The study found that activating the 5-HT2C receptor using the drug lorcaserin effectively reduced alcohol self-administration, drinking, and seeking behavior in both male and female rats. In contrast, blocking the 5-HT2A receptor with pimavanserin had a limited effect on these behaviors. These findings highlight the potential of targeting serotonin receptors, particularly the 5-HT2C subtype, as a novel strategy for treating alcohol addiction.

Hope for a Sober Future

This research offers a glimmer of hope for individuals struggling with alcohol addiction. It suggests that targeting the 5-HT2C receptor may provide a new avenue for developing effective therapies. However, as with navigating a vast and unpredictable desert, further research is crucial to understand the nuances of this complex relationship and to ensure the safety and efficacy of any potential therapies.

Dr. Camel's Conclusion

This research, like a beacon in the desert, offers hope for those struggling with alcohol addiction. The findings point to the potential of manipulating serotonin receptors, especially the 5-HT2C subtype, as a promising therapeutic strategy. It's a journey of discovery, with the potential to lead to new and effective treatments for this challenging condition.

Date :
  1. Date Completed 2022-07-07
  2. Date Revised 2022-07-12
Further Info :

Pubmed ID

35644487

DOI: Digital Object Identifier

10.1016/j.neuropharm.2022.109150

Related Literature

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・Effects of lorcaserin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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