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Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway.

Author: AndradeCarolina Horta, CavalcanteTalita Matias Barbosa, FilhoAdriano José Maia Chaves, JucáPaloma Marinho, LopesIardja Stéfane, MacedoDanielle S, MendonçaSabrina Silva, MottinMelina, OliveiraJoão Victor Souza, de CarvalhoMichele Albuquerque Jales, de França FontelesMarta Maria, de LimaKlistenes Alves, de SousaFrancisca Cléa Florenço, de SouzaAlana Gomes

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that dimethyl fumarate (DMF) can exert neuroprotective effects against depression-like behaviors by modulating astrocytes and microglia. DMF reversed CUMS-induced anxiety- and depressive-like behaviors and cognitive deficits, suggesting that its antidepressant effect may be mediated through neuroinflammatory suppression.
Paper Details　
Original Abstract of the Article :
We postulated that dimethyl fumarate (DMF) exerts neuroprotective effects against depression-like behaviors through astrocytes and microglia modulation. To ascertain our hypothesis and define the mechanistic pathways involved in effect of DMF on neuroinflammation, we used the depression model induce...See full text at original site
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引用元：
https://doi.org/10.1007/s00210-022-02247-x

データ提供：米国国立医学図書館（NLM）

Dimethyl Fumarate: A Promising Oasis in the Desert of Depression

This research investigates the potential of dimethyl fumarate (DMF), a medication currently used for multiple sclerosis, to treat depression. Researchers, like explorers venturing into uncharted territory, investigated the neuroprotective effects of DMF, focusing on its ability to modulate astrocytes and microglia, key players in the brain's immune system.

A New Pathway to Hope in the Desert of Depression

The study, using a mouse model of depression, found that DMF significantly alleviated depression-like behaviors, reduced neuroinflammation, and improved cognitive function. This suggests that DMF may offer a novel treatment option for depression, potentially working by modulating the brain's immune response.

Navigating the Desert of Mental Health with DMF

This research offers a glimmer of hope for individuals struggling with depression, suggesting that DMF may hold promise as a potential treatment. Further research is needed to confirm these findings and explore the safety and efficacy of DMF for treating depression in humans.

Dr.Camel's Conclusion

This study reveals the potential of dimethyl fumarate as a novel treatment for depression, like discovering a hidden oasis in the vast desert of mental health challenges. It's a reminder that even in the most challenging landscapes, hope can be found, and new solutions are always emerging.

Date :
  1. Date Completed 2022-08-30
  2. Date Revised 2022-09-02
Further Info :

Pubmed ID

35665831

DOI: Digital Object Identifier

10.1007/s00210-022-02247-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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