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Original Abstract of the Article :
The graded and quantal responses of metoclopramide (MCL, Paspertin) were studied in patients (17-71 years) treated with cisplatin in combination with other cytostatics. The lowest dose of MCL was 0.125 mg/kg b.w./h i.v. over 2 h as loading infusion, then 0.0625 mg/kg/h over 24 h as the maintenance i...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3566848
データ提供:米国国立医学図書館(NLM)
Metoclopramide: A Desert Oasis Against Cisplatin-Induced Nausea and Vomiting
Cisplatin, a powerful chemotherapy drug, can cause severe nausea and vomiting, making the journey through cancer treatment incredibly difficult. This study explores the effectiveness of metoclopramide, an antiemetic drug, in preventing these side effects. The researchers studied the dose-response relationship between metoclopramide and cisplatin, investigating how different doses of metoclopramide affect the severity of nausea and vomiting. It's like finding the perfect blend of water and shade to survive a scorching desert.Finding the Right Balance: Metoclopramide Shows Promise for Nausea and Vomiting Control
This research provides valuable information for optimizing the use of metoclopramide in patients receiving cisplatin chemotherapy. The study found that higher doses of metoclopramide were associated with a greater reduction in nausea and vomiting. This is a significant finding, as it offers a potential solution for a common and debilitating side effect of chemotherapy. This research also suggests that it is possible to fine-tune the dosage of metoclopramide based on the specific dose of cisplatin being administered, helping to minimize side effects and improve patient comfort.Understanding the Balance: Minimizing Side Effects While Maximizing Treatment Effectiveness
While metoclopramide is a valuable tool for managing nausea and vomiting associated with cisplatin chemotherapy, it's important to be aware of potential side effects. Just as a desert traveler must carefully manage their water intake, healthcare professionals must carefully monitor patients receiving metoclopramide to minimize the risk of adverse effects. This research underscores the importance of finding the right balance between treatment benefits and potential risks, ensuring the best possible outcome for patients.Dr.Camel's Conclusion
This study demonstrates the potential of metoclopramide to significantly reduce nausea and vomiting associated with cisplatin chemotherapy. By understanding the dose-response relationship between these two drugs, healthcare professionals can better manage side effects and improve the quality of life for patients undergoing cancer treatment. It's a reminder that even in the harsh desert of cancer treatment, there are ways to find relief and navigate the journey more comfortably.Date :
- Date Completed 1987-04-29
- Date Revised 2013-11-21
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