Paper Details

  1. Home
  2. Paper Details

Gold nanoparticles capped DHPMs for meliorate detection of antiretroviral drug: Azidothymidine.

Author: BhardwajGeetika, KaurNavneet, KaurRandeep, SinghNarinder

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed a cost-effective and easy-to-use chemosensor for azidothymidine (AZT), an anti-HIV drug. The sensor is based on a Biginelli-based receptor and shows high selectivity for AZT among various thymidine analogs. The detection limit of the sensor is 6 nM, making it suitable for monitoring AZT levels in patients undergoing treatment.
Paper Details　
Original Abstract of the Article :
Anti-human immunodeficiency (HIV)-drug azidothymidine interferes with the reverse transcriptase enzyme, which results in reduced activity of HIV thereby inhibiting the growth of the virus. Owing to the side effects of high doses and short half-life of this antiviral drug azidothymidine (AZT): a fast...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.talanta.2022.123591

データ提供：米国国立医学図書館（NLM）

Gold Nanoparticles Capped DHPMs for Detection of Antiretroviral Drug AZT

This study focuses on the development of a novel, highly sensitive method for detecting the antiretroviral drug AZT. The researchers synthesized a Biginelli-based receptor and explored its sensing properties using various techniques, including UV-Visible spectroscopy, circular dichroism (CD), and cyclic voltammetry (CV). The primary objective of this research was to create a rapid and reliable sensor for AZT, which can be crucial for monitoring patient treatment and ensuring drug efficacy.

A Novel Sensor for AZT Detection

The study successfully developed a highly sensitive sensor for AZT, with a detection limit of 6 nM. This sensor utilizes gold nanoparticles capped DHPMs, demonstrating improved response on CV, Differential pulse voltammetry (DPV), and linear sweep voltammetry (LSV). This breakthrough could have significant implications for the management of HIV patients.

Implications for HIV Treatment and Monitoring

This study offers a promising new tool for HIV treatment and monitoring. The sensitive and reliable detection of AZT could help ensure optimal drug levels in patients, potentially leading to improved treatment outcomes and reduced side effects. The development of such a sensor could be a significant advancement in the fight against HIV.

Dr.Camel's Conclusion

Imagine a camel traversing the desert, searching for an oasis. Just like this camel needs a reliable guide to find the water, HIV patients need accurate and timely monitoring of their medications. This research provides a novel sensor that acts like a beacon, helping healthcare professionals navigate the complexities of HIV treatment and ensuring that patients have access to the right resources for their journey towards health.

Date :
  1. Date Completed 2022-09-07
  2. Date Revised 2022-09-07
Further Info :

Pubmed ID

35688073

DOI: Digital Object Identifier

10.1016/j.talanta.2022.123591

Related Literature

Article Analysis
・Side Effects of azt
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.