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Inflammation-targeted sialic acid-dexamethasone conjugates for reducing the side effects of glucocorticoids.

Author: ChenGuoliang, GouJingxin, HeHaibing, JiMuse, LiuDongdong, LiuHongbing, QinYi, TangXing, WangNa, XiaoPeifu, YinTian, ZhangYu, ZhaoJiansong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes the synthesis and evaluation of a sialic acid (SA)-modified dexamethasone conjugate (Dex-SA) to reduce the side effects of dexamethasone (Dex) while maintaining its therapeutic efficacy for inflammatory diseases. Dex-SA showed increased water solubility, improved stability in plasma, and selective uptake by inflammatory cells. It also demonstrated comparable therapeutic effects to Dex while significantly reducing Dex-related side effects.
Paper Details　
Original Abstract of the Article :
As a potent glucocorticoid drug (GCs), Dexamethasone (Dex) is widely used clinically for the treatment of inflammatory diseases. However, such side effects as Cushing's syndrome and osteoporosis caused severe distress to patients. Herein, a sialic acid (SA)-modified dexamethasone conjugate (Dex-SA) ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2022.121900

データ提供：米国国立医学図書館（NLM）

Inflammation-Targeted Glucocorticoids: A New Approach to Reducing Side Effects

Glucocorticoids are powerful medications used to treat inflammatory conditions, but they can also have significant side effects. This study investigates a novel approach to reducing these side effects by targeting glucocorticoids specifically to inflammatory sites. The researchers developed a sialic acid (SA)-modified dexamethasone conjugate (Dex-SA) that aims to deliver dexamethasone selectively to inflammatory cells.

Targeted Delivery: A More Precise Approach to Treatment

The study found that Dex-SA was more readily taken up by inflammatory cells compared to dexamethasone alone, suggesting that this targeted delivery approach could enhance therapeutic effects while minimizing side effects. It's like a caravan traveling through a desert – targeting the delivery of resources to specific areas can make the journey more efficient and effective.

Reducing Side Effects: A Step Towards Safer Treatment

The study provides promising results for reducing the side effects associated with glucocorticoids. The findings suggest that Dex-SA could offer a safer and more effective treatment option for inflammatory diseases. This research is a refreshing oasis in the desert of drug development, offering a new approach to treating inflammatory diseases.

Dr. Camel's Conclusion

This study explores a new approach to delivering glucocorticoids, aiming to minimize side effects and enhance therapeutic effects. The development of Dex-SA represents a potential breakthrough in the treatment of inflammatory diseases, offering a safer and more targeted approach. This is a promising oasis in the desert of drug development, providing a source of hope for patients and researchers alike.

Date :
  1. Date Completed 2022-06-21
  2. Date Revised 2022-06-23
Further Info :

Pubmed ID

35690305

DOI: Digital Object Identifier

10.1016/j.ijpharm.2022.121900

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・Side Effects of dexamethasone
SNS
PICO Info
in preparation
Languages

English

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