Paper Details
- Home
- Paper Details
Mannose-targeting Concanavalin A-Epirubicin Conjugate for Targeted Intravesical Chemotherapy of Bladder Cancer.
Author: BuHuagang, DingLin, GuoYuna, HuangTengfei, HuoFan, JiaRu, LiPengchao, LiWei, LiYiran, WangLan, YanChao, ZhangWeiyi, ZhangYaliang, ZhangYang
Original Abstract of the Article :
Intravesical instillation of chemotherapeutic drugs such as epirubicin (EPI) is routinely used to prevent tumor recurrence and progression after transurethral resection of bladder tumor. However, the lack of tumor selectivity often causes severe damage to normal bladder urothelium leading to intoler...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1002/asia.202200342
データ提供：米国国立医学図書館（NLM）
Targeted Intravesical Chemotherapy for Bladder Cancer: A New Oasis in the Desert of Cancer Treatment
Bladder cancer, a common and often aggressive malignancy, presents significant challenges for treatment. Intravesical chemotherapy, a standard treatment approach, involves delivering chemotherapy directly to the bladder. However, this method can cause damage to normal bladder tissue, leading to side effects. This research explores a novel approach to targeted intravesical chemotherapy using a lectin-drug conjugate, aiming to improve efficacy and minimize toxicity.
A New Path to Precision Chemotherapy: Navigating the Desert of Bladder Cancer
The authors identified mannose as a potential target for bladder cancer therapy, as it is aberrantly expressed on the surface of bladder cancer cells. They developed a mannose-targeting Concanavalin A-Epirubicin conjugate that selectively targets cancer cells, potentially reducing damage to normal tissues. Preclinical studies show promising results, demonstrating the potential of this approach for targeted intravesical chemotherapy.
A Glimmer of Hope in the Desert: Targeted Therapy for Bladder Cancer
This research presents a promising new strategy for the treatment of bladder cancer. The use of a mannose-targeting lectin-drug conjugate offers the potential for more effective and targeted chemotherapy, minimizing damage to normal tissues and improving patient outcomes. As with a camel seeking a hidden oasis in a vast desert, this research offers a glimmer of hope for those navigating the challenges of bladder cancer treatment.
Dr. Camel's Conclusion
This research explores a novel and promising approach to targeted intravesical chemotherapy for bladder cancer, utilizing a mannose-targeting lectin-drug conjugate. The preclinical studies demonstrate the potential of this strategy for improving therapeutic efficacy and minimizing toxicity. This research represents a significant step forward in the ongoing quest for more effective and targeted cancer therapies, offering a beacon of hope in the vast desert of cancer treatment.
Date :
- Date Completed 2022-08-18
- Date Revised 2022-08-18
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.