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Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damage.

Author: ChenXiuying, GuChao, GuanHaiyun, LiBin, TangZhijing, XiaHexia, XuYan, ZhangWei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of rapamycin on ovarian follicle activation and development in a cyclophosphamide (CTX)-treated mouse model. Rapamycin was found to inhibit primordial follicle activation and reduce follicle loss and apoptosis, suggesting that it may have potential as an ovarian-protective agent for preserving fertility in young cancer patients undergoing chemotherapy.
Paper Details　
Original Abstract of the Article :
Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer. Herein, we investigated the effects of rapamycin on the activation and development of ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334315/

データ提供：米国国立医学図書館（NLM）

Preserving Fertility: Protecting the Oasis Against Sandstorms

This study investigates the effects of rapamycin, a drug that helps regulate cell growth, on the ovarian reserve, which is like a precious oasis of eggs essential for fertility. The researchers used a mouse model to explore how rapamycin could protect the ovarian reserve from the damaging effects of cyclophosphamide, a chemotherapy drug that can act like a sandstorm, destroying the oasis's vital resources.

A Shield Against the Sandstorm

The researchers found that rapamycin successfully protected the ovarian reserve from cyclophosphamide-induced damage, acting like a protective shield against the sandstorm. The drug prevented the premature activation of eggs, minimized cell death, and preserved the overall health of the ovaries.

Finding New Ways to Protect the Oasis

This study provides hope for young cancer patients who are concerned about preserving their fertility. The researchers believe that rapamycin could be a valuable tool for safeguarding the ovarian reserve and promoting future reproductive potential. It's like finding a hidden spring that revitalizes the oasis, offering hope for continued life and growth.

Dr. Camel's Conclusion

This study, like a refreshing breeze in the desert, brings hope for preserving fertility in young cancer patients. Rapamycin, like a well-placed oasis, provides a potential solution for mitigating the harmful effects of chemotherapy on ovarian function. The researchers emphasize the importance of ongoing research to optimize this approach and further protect the delicate balance of fertility in cancer patients.
Date :
  1. Date Completed 2023-10-06
  2. Date Revised 2023-10-06
Further Info :

Pubmed ID

35718464

DOI: Digital Object Identifier

PMC9334315

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Languages

English

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