Proposed European Competence Network on Mastocytosis-American Initiative in Mast Cell Diseases (ECNM-AIM) Response Criteria in Advanced Systemic Mastocytosis.

Author: AkinCem, ArockMichel, BonadonnaPatrizia, BrockowKnut, ButterfieldJoseph H, CarterMelody C, CastellsMariana, ElberinkHanneke Oude, GeorgeTracy I, GotlibJason, HartmannKarin, HermineOlivier, HoermannGregor, HornyHans-Peter, LyonsJonathan J, LübkeJohannes, MetcalfeDean D, NiedoszytkoMarek, OrfaoAlberto, RadiaDeepti H, ReiterAndreas, SchwaabJuliana, SchwartzLawrence B, ShomaliWilliam, SiebenhaarFrank, SotlarKarl, SperrWolfgang R, TriggianiMassimo, UstunCelalettin, ValentPeter, ZanottiRoberta, Álvarez-TwoseIvan

Paper Details 
Original Abstract of the Article :
Advanced systemic mastocytosis (AdvSM) is characterized by the presence of KIT D816V and other somatic mutations (eg, in SRSF2, ASXL1, and RUNX1) in 95% and 60% to 70% of patients, respectively. The biological and clinical consequences of AdvSM include multilineage involvement (eg, associated hemato...See full text at original site
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引用元:
https://doi.org/10.1016/j.jaip.2022.05.034

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Mastocytosis

Mastocytosis, a rare disorder characterized by the overgrowth of mast cells, is like a hidden oasis in the desert, both beautiful and potentially dangerous. This article, published in the journal Blood, explores the development of response criteria for advanced systemic mastocytosis (AdvSM), a severe form of mastocytosis that can affect various organs and systems.

Mapping the Terrain: Response Criteria for Mastocytosis

The authors discuss the evolution of response criteria for AdvSM, comparing it to a map that helps navigate the complexities of the disease. They recognize the need for refined criteria to accurately assess treatment response and track patient outcomes.

Finding the Oasis: Improved Treatment Strategies

This research, like a beacon in the desert, sheds light on the importance of developing robust response criteria to guide treatment decisions for AdvSM. By accurately measuring treatment efficacy and monitoring patient progress, clinicians can optimize treatment strategies and improve patient outcomes.

Dr. Camel's Conclusion

This article underscores the importance of accurate assessment in the treatment of AdvSM. By developing and refining response criteria, clinicians can better navigate the challenging terrain of this complex disease, offering hope for patients seeking relief from its debilitating symptoms.

Date :
  1. Date Completed 2022-08-16
  2. Date Revised 2022-09-16
Further Info :

Pubmed ID

35724948

DOI: Digital Object Identifier

10.1016/j.jaip.2022.05.034

Related Literature

SNS
PICO Info
in preparation
Languages

English

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