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A Case Report of Tolvaptan Therapy for ADPKD Patients With COVID-19. The Need for Appropriate Counselling for Temporary Drug Discontinuation.

Author: AielloValeria, CapelliIrene, GhediniLaura, IacovellaFrancesca, LA MannaGaetano, MarconiLorenzo, MasinaMarco, NapoletanoAngelodaniele, VialePierluigi

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vasopressin receptor antagonists, like Tolvaptan, are used to slow the progression of autosomal dominant polycystic kidney disease (ADPKD). While common side effects include polyuria, nocturia, and polydipsia, elevated liver enzyme levels can also occur. Temporary drug withdrawal may be necessary in cases of dehydration, especially during the COVID-19 pandemic.
Paper Details　
Original Abstract of the Article :
Patients with autosomal dominant polycystic kidney disease (ADPKD) may require specific therapy with vasopressin receptor antagonists to slow the progression of renal disease. Because of its mechanism of action, the most common side effects are polyuria, nocturia, and polydipsia. Elevations of liver...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301397/

データ提供：米国国立医学図書館（NLM）

Tolvaptan Therapy in ADPKD Patients with COVID-19

This case report examines the management of patients with autosomal dominant polycystic kidney disease (ADPKD) who develop COVID-19 while receiving Tolvaptan therapy. Tolvaptan, a vasopressin receptor antagonist, is often used to slow the progression of kidney disease in ADPKD. The authors highlight the importance of careful consideration regarding the potential need for temporary discontinuation of Tolvaptan in ADPKD patients who develop COVID-19. This is due to the risk of dehydration associated with COVID-19, which could exacerbate the side effects of Tolvaptan.

Navigating Tolvaptan Therapy in the Context of COVID-19

This case report underscores the importance of individualized management of ADPKD patients who develop COVID-19 while on Tolvaptan therapy. Careful monitoring for signs of dehydration and appropriate counseling regarding the potential need for temporary drug discontinuation are crucial for ensuring patient safety.

Managing ADPKD in the Era of COVID-19

This report emphasizes the need for healthcare providers to be aware of the potential challenges associated with managing ADPKD patients who develop COVID-19. Open communication with patients and close monitoring for signs of dehydration are essential for optimizing treatment outcomes and ensuring patient safety.

Dr.Camel's Conclusion

Just as a camel must adapt its drinking habits to the limited water sources in the desert, ADPKD patients on Tolvaptan therapy may need to adjust their medication regimen in the context of COVID-19. This case report serves as a reminder for healthcare providers to be mindful of the potential for dehydration and the importance of individualized patient care.

Date :
  1. Date Completed 2022-06-27
  2. Date Revised 2022-08-02
Further Info :

Pubmed ID

35738624

DOI: Digital Object Identifier

PMC9301397

Related Literature

Article Analysis
・Side Effects of tolvaptan (kidney disease)
SNS
PICO Info
in preparation
Languages

English

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