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Antinociceptive and Analgesic Effects of (2<i>R</i>,6<i>R</i>)-Hydroxynorketamine.

Author: BrowneCaroline A, LuckiIrwin, WulfHildegard A, YostJonathan G

Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

(2R,6R)-hydroxynorketamine (HNK), a ketamine metabolite, has shown potential for pain relief without the significant side effects associated with ketamine. This study compared the antinociception activity of ketamine and HNK in mice. HNK produced late-developing antinociception, suggesting involvement of AMPA receptor-dependent glutamatergic mechanisms. Additionally, HNK reversed mechanical allodynia in a neuropathic pain model, demonstrating comparable short-term efficacy to gabapentin but outperforming it at 24 hours. These findings support further investigation of HNK as a potential non-opioid analgesic.
Paper Details　
Original Abstract of the Article :
Commonly used pain therapeutics, such as opioid medications, exert dangerous side effects and lack effectiveness in treating some types of pain. Ketamine is also used to treat pain, but side effects limit its widespread use. (2<i>R</i>,6<i>R</i>)-hydroxynorketamine (HNK) is a ketamine metabolite tha...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426759/

データ提供：米国国立医学図書館（NLM）

Unlocking the Potential of (2R,6R)-Hydroxynorketamine: A New Hope for Pain Relief

Pain is a universal experience, often a relentless companion. This research investigates the potential of (2R,6R)-hydroxynorketamine (HNK), a ketamine metabolite, as a novel analgesic agent. The authors compared the effects of HNK and ketamine on pain perception in mice, exploring the mechanisms behind their pain-relieving properties.

A Different Approach to Pain Management

The researchers discovered that HNK produced a delayed, long-lasting analgesic effect compared to the immediate but short-lived effect of ketamine. Moreover, HNK showed a superior safety profile, causing fewer side effects than ketamine. It's like discovering a hidden oasis in the desert, providing a safe haven from the scorching sun and thirst.

A Promising Future for Pain Treatment

The findings suggest that HNK could offer a promising alternative to conventional pain medications, potentially providing more effective and sustained pain relief with fewer side effects. It's like finding a new path through a treacherous desert, leading to a more comfortable and sustainable journey.

Dr. Camel's Conclusion

This research offers hope for a new generation of pain medications. HNK shows promise in treating various types of pain, potentially offering a safe and effective alternative to traditional analgesics. I am excited to see how this research progresses and the potential it holds for improving the lives of countless individuals who suffer from chronic pain.

Date :
  1. Date Completed 2022-08-18
  2. Date Revised 2023-09-02
Further Info :

Pubmed ID

35779947

DOI: Digital Object Identifier

PMC9426759

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