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Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists.

Author: HeinzBeverly A, HuangXiaofang, JohnsonKirk W, LiBaolin, LiXia, YuJianliang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Blocking the CGRP receptor, but not the CGRP ligand, had a greater impact on gastrointestinal transit. This finding may be related to opposing mechanisms between the CGRP and AMY1 receptors, suggesting that CGRP ligand antibodies could inhibit the effects of CGRP at both the CGRP and AMY1 receptors.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To characterize the effects of blocking calcitonin gene-related peptide (CGRP) activity in a mouse model of gastrointestinal transport. BACKGROUND: Migraine management using CGRP modulating therapies can cause constipation of varying frequency and severity. This variation might be due to...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545683/

データ提供：米国国立医学図書館（NLM）

Understanding the Impact of CGRP Modulating Therapies on Gastrointestinal Transit

We're diving into the fascinating realm of neurogastroenterology, examining the effects of calcitonin gene-related peptide (CGRP) modulating therapies on gastrointestinal transit. This study investigates the impact of different CGRP-blocking therapies on gastrointestinal transit in a mouse model. The research explores the potential for constipation as a side effect of CGRP-modulating therapies and investigates the underlying mechanisms responsible for this adverse effect.

CGRP Modulating Therapies and Gastrointestinal Transit

This study reveals that blocking the CGRP receptor, either through antibody or small molecule antagonist, can significantly impact gastrointestinal transit, potentially leading to constipation. The research highlights the importance of considering the potential gastrointestinal side effects of these therapies and exploring strategies for minimizing their occurrence. The findings, like a hidden spring in the desert, offer valuable insights into the potential mechanisms underlying this adverse effect.

Managing Gastrointestinal Side Effects of CGRP Therapies

CGRP-modulating therapies, while effective for migraine management, can cause constipation in some individuals. This study highlights the importance of monitoring gastrointestinal symptoms and addressing them proactively. Consulting with your healthcare provider and exploring strategies for managing constipation can help optimize treatment outcomes.

Dr.Camel's Conclusion

This research, like a caravan traversing the vast desert of gastrointestinal physiology, provides valuable insights into the impact of CGRP-modulating therapies on gastrointestinal transit. The study underscores the importance of considering the potential for constipation as a side effect of these therapies and exploring strategies for mitigating this adverse effect.

Date :
  1. Date Completed 2022-08-09
  2. Date Revised 2022-10-15
Further Info :

Pubmed ID

35822594

DOI: Digital Object Identifier

PMC9545683

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Languages

English

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