Efficacy of auranofin as an inhibitor of desmoid progression.

Author: AlmanBenjamin A, EnomotoAtsushi, HamadaShunsuke, IkutaKunihiro, ImagamaShiro, ItoKan, KoikeHiroshi, NishidaYoshihiro, OhkawaraBisei, OhnoKinji, SakaiTomohisa, ShimizuKoki, ZhangJiarui

Paper Details 
Original Abstract of the Article :
Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against DF by drug repositioning, and evaluate its efficacy. FDA-a...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279441/

データ提供:米国国立医学図書館(NLM)

Auranofin: A Potential New Weapon Against Desmoid Fibromatosis

Desmoid-type fibromatosis (DF) is a rare but aggressive type of tumor that can be as formidable as a shifting sand dune, challenging conventional treatment approaches. This study explores the potential of auranofin, a drug currently used for rheumatoid arthritis, as a new therapeutic strategy for DF. The researchers used drug repositioning, an innovative approach akin to finding a hidden oasis in the vast desert of existing medications, to evaluate the efficacy of auranofin against DF cells. They discovered that auranofin effectively inhibited the proliferation of DF cells, demonstrating the potential for this existing drug to offer a new treatment option for this challenging condition.

Auranofin Shows Promise for Desmoid Fibromatosis Treatment

The study indicates that auranofin, a drug with a known safety profile, may offer a promising treatment option for DF, potentially reducing the reliance on more aggressive therapies that often come with substantial side effects. The researchers observed that auranofin effectively inhibited the development of tumorous tissues in animal models, suggesting that this drug could provide a new avenue for treating DF. This discovery is like finding a hidden spring in the desert of treatment options for DF, offering potential relief for those facing this challenging condition.

Exploring New Therapeutic Horizons

This research highlights the potential of drug repositioning to unearth new treatment options for rare and challenging conditions. By exploring the existing therapeutic landscape, we can potentially find new solutions for diseases that have previously been difficult to manage. This study serves as a reminder that the desert of medical research is filled with hidden treasures waiting to be discovered, offering potential new avenues for healing and recovery.

Dr. Camel's Conclusion

This study illustrates the power of repurposing existing drugs to find innovative solutions for challenging conditions. Auranofin, once a treatment for rheumatoid arthritis, may hold the key to effectively combatting desmoid fibromatosis. It's a testament to the boundless potential of medical research to transform lives and offer hope in even the most challenging circumstances.

Date :
  1. Date Completed 2022-07-15
  2. Date Revised 2022-09-20
Further Info :

Pubmed ID

35831372

DOI: Digital Object Identifier

PMC9279441

Related Literature

SNS
PICO Info
in preparation
Languages

English

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