The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review.

Author: DuqueGustavo, LimAnthony, LinHong, SalechFelipe, VogrinSara

Paper Details 
Original Abstract of the Article :
BACKGROUND: Preclinical studies have shown a therapeutic role of the mechanistic/mammalian target of rapamycin complex 1 (mTORC1) inhibition with rapamycin and its analogues (rapalogues) on several age-related musculoskeletal disorders (MSKD). However, the applicability to humans of these findings i...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637607/

データ提供:米国国立医学図書館(NLM)

Rapamycin and Its Analogues: Targeting Age-Related Musculoskeletal Diseases

As we age, our bodies can experience a range of changes, including those affecting our bones, muscles, and joints. This study explores the potential of rapamycin and its analogues, known as rapalogues, in treating age-related musculoskeletal diseases. The authors conducted a systematic review, gathering and analyzing existing research on the effects of rapalogues on human health.

The study highlights the promising preclinical evidence for rapalogues in addressing age-related musculoskeletal disorders. However, it cautions that the applicability of these findings to humans remains uncertain. The authors reviewed fourteen studies and found that while rapalogues show potential in various aspects of musculoskeletal health, more research is needed to establish their clinical efficacy and safety. This is a crucial step in translating promising preclinical findings into real-world applications.

Rapalogues: A Potential Tool for Age-Related Musculoskeletal Health

This study provides a fascinating glimpse into the potential of rapalogues for addressing age-related musculoskeletal diseases. While more research is needed to confirm their efficacy and safety in humans, the findings suggest a promising avenue for future therapeutic development.

Maintaining Musculoskeletal Health: A Lifelong Journey

This research reminds us that maintaining our musculoskeletal health is a lifelong journey, especially as we age. It highlights the need for continued research to uncover new and effective therapies for age-related musculoskeletal diseases. As we traverse the sands of time, it's important to stay informed about emerging therapies and maintain a healthy lifestyle to support our musculoskeletal well-being.

Dr. Camel's Conclusion

This systematic review delves into the potential of rapalogues for addressing age-related musculoskeletal diseases. While the research is still in its early stages, it offers a glimpse into the fascinating world of aging and its impact on our bodies. The authors' findings highlight the importance of continued research and exploration in this field, as we seek to understand and treat the challenges of aging. As we navigate the sands of time, it's important to embrace new discoveries and possibilities, always searching for ways to improve our health and well-being.

Date :
  1. Date Completed 2022-11-08
  2. Date Revised 2022-11-09
Further Info :

Pubmed ID

35861940

DOI: Digital Object Identifier

PMC9637607

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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