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Systemic absorption of adrenaline after aerosol, eye-drop and subcutaneous administration to healthy volunteers.
Author: DahlöfC, MellstrandT, SvedmyrN
Original Abstract of the Article :
Adrenaline is the drug of choice for management of the anaphylactic reaction. The objective of this study was to compare systemic absorption of adrenaline after administration by different routes to healthy volunteers. Ten puffs (1.5 mg as adrenaline base) with 10-15 s intervals between them followe...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/j.1398-9995.1987.tb02202.x
データ提供:米国国立医学図書館(NLM)
Systemic Absorption of Adrenaline: A Journey Through Different Routes
Imagine a camel caravan traversing the vast desert. Each route presents unique challenges and opportunities. Similarly, adrenaline, the drug of choice for managing anaphylactic reactions, shows varying levels of systemic absorption depending on how it's administered. In this study, researchers compared the absorption of adrenaline after it was delivered through the following routes: inhalation, eye drops, and subcutaneous injection.
Adrenaline's Journey: A Tale of Absorption
The study found that administering adrenaline as eye drops had no significant effect on systemic absorption. However, subcutaneous administration led to a significant increase in plasma adrenaline levels, accompanied by changes in blood pressure, heart rate, and tremor. The results highlight the variability in adrenaline absorption depending on the delivery route.
Understanding Adrenaline's Impact
Adrenaline is a powerful drug that plays a vital role in managing anaphylactic reactions, a life-threatening allergic response. Understanding how adrenaline is absorbed depending on the delivery route is crucial for optimizing treatment strategies. It's like knowing the best path to navigate through a desert, ensuring the safe and efficient delivery of vital resources.
Dr. Camel's Conclusion
This research sheds light on the fascinating journey of adrenaline through our bodies. By understanding the different routes of administration and their impact on systemic absorption, we can better manage allergic reactions and ensure the safety and effectiveness of this crucial medication.
Date :
- Date Completed 1987-07-16
- Date Revised 2019-08-20
Further Info :
Related Literature
English
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