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An Open-Label Study to Evaluate the Effect of Eluxadoline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Participants.
Author: BoinpallyRamesh, KaczynskiEdward, McGeeneyDanielle, WeissmanDarren
Original Abstract of the Article :
Eluxadoline is a mixed μ-opioid, κ-opioid receptor agonist, and δ-opioid receptor antagonist, approved in the United States for adults with diarrhea-predominant irritable bowel syndrome. This phase 1, single-center, open-label, single-sequence study was conducted on 30 healthy participants to establ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805131/
データ提供:米国国立医学図書館(NLM)
Eluxadoline: No Clinically Significant Effect on Midazolam Pharmacokinetics
Medications, like desert plants, can interact in unexpected ways. This study investigated the potential interaction between eluxadoline, a drug used to treat diarrhea-predominant irritable bowel syndrome, and midazolam, a commonly used sedative. The researchers wanted to determine if eluxadoline could affect the body's processing of midazolam.
Eluxadoline Does Not Significantly Affect Midazolam Metabolism
The study found that eluxadoline did not have a clinically significant effect on the pharmacokinetics of midazolam, suggesting that it is unlikely to affect the effectiveness of other medications metabolized by the same enzyme.
Navigating the Desert of Drug Interactions
This research provides reassurance about the safety of eluxadoline in combination with other medications. However, it is always important to consult with a healthcare professional to discuss potential drug interactions and ensure safe and effective treatment outcomes.
Dr. Camel's Conclusion
This study provides valuable information about the drug interaction profile of eluxadoline. It highlights the importance of understanding potential drug interactions, just as a camel needs to be aware of the hidden dangers of the desert. This research reinforces the need for ongoing vigilance and careful consideration of medication combinations to ensure patient safety.
Date :
- Date Completed 2022-11-02
- Date Revised 2023-01-25
Further Info :
Related Literature
English
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