Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine.

Author: AkatoriHaruka, ArakawaKazuhiko, GondohEizoh, HamadaYusuke, HigashiyamaKimio, InadaEiichi, IsekiMasako, IwazawaYusuke, KuzumakiNaoko, MiyanoKanako, MoriTomohisa, NaritaMichiko, NaritaMinoru, SatoDaisuke, ShinoharaAsami, SudaYukari, TanakaKenichi, TezukaHiroyuki, TsujimuraMayu, YamashitaKensuke, YamauchiTakayasu, YoshidaSara

Paper Details 
Original Abstract of the Article :
BACKGROUND: It has been considered that activation of peripheral μ-opioid receptors (MORs) induces side effects of opioids. In this study, we investigated the possible improvement of the immune system in tumour-bearing mice by systemic administration of the peripheral MOR antagonist naldemedine. ME...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553910/

データ提供:米国国立医学図書館(NLM)

Boosting the Immune System: A New Approach to Cancer Treatment

The world of immunology is a vast desert, with researchers constantly searching for new oases of knowledge. This study, published in the journal [論文掲載誌], presents a fascinating approach to bolstering the immune system in the fight against cancer. The study focuses on the potential of blocking peripheral μ-opioid receptors (MORs) as a way to enhance immune function.

Targeting Opioid Receptors to Combat Cancer

The study employed a strategy reminiscent of a caravan navigating a treacherous desert: blocking specific pathways to achieve a desired outcome. In this case, the researchers used naldemedine, a peripheral MOR antagonist, to block the signaling of these receptors in mice with tumors. They discovered that this blockade not only reduced tumor growth but also significantly prolonged survival in these mice. This is a truly exciting discovery!

The Potential for a New Treatment Strategy

The results suggest that blocking peripheral MORs might be a promising avenue for developing new cancer treatments. This approach could potentially improve the effectiveness of existing therapies, creating a more favorable landscape for cancer patients. As Dr. Camel, I find these findings extremely promising! This research offers hope for a future where we can more effectively combat cancer by unlocking the hidden potential of the immune system.

Dr.Camel's Conclusion

This study is a testament to the ongoing quest for new cancer treatment strategies. The authors have provided strong evidence that targeting peripheral μ-opioid receptors may hold the key to enhancing immune function and combating cancer. As we continue to explore the vast expanse of immunology, research like this provides critical stepping stones on the path to a healthier future.
Date :
  1. Date Completed 2022-10-13
  2. Date Revised 2023-08-10
Further Info :

Pubmed ID

35945243

DOI: Digital Object Identifier

PMC9553910

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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