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The discriminative stimulus effects of baclofen and gamma hydroxybutyrate in C57BL/6J mice.

Author: HiranitaTakato, KoekWouter, McMahonLance R, WilkersonJenny L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Baclofen and γ-hydroxybutyrate (GHB) have distinct pharmacological activities despite sharing GABA<sub>B</sub> receptor agonism. This study used discriminative stimulus assays in mice to assess their effects and the role of GABA<sub>B</sub> receptors.
Paper Details　
Original Abstract of the Article :
Baclofen and γ-hydroxybutyrate (GHB) exert γ-aminobutyric acid (GABA)B receptor agonism and have therapeutic utility but possess different pharmacological activities. We examined whether separate groups of mice could be trained to discriminate either baclofen or GHB, and the contribution of GABAB re...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35947069

データ提供：米国国立医学図書館（NLM）

Exploring the Discriminative Stimulus Effects of Baclofen and Gamma Hydroxybutyrate

The field of [pharmacology] is constantly seeking to understand the mechanisms of action of different drugs and their potential for therapeutic use. This research investigates the discriminative stimulus effects of [baclofen] and [gamma hydroxybutyrate] in mice, exploring their interaction with [GABA B receptors]. The study utilizes a [drug discrimination] paradigm to assess the contribution of [GABA B receptors] to the discriminative stimulus effects of these drugs. The findings provide valuable insights into the pharmacological properties of [baclofen] and [gamma hydroxybutyrate] and their potential therapeutic applications.

GABA B Receptors Play a Key Role in Baclofen and GHB Effects

This research demonstrates the critical role of [GABA B receptors] in mediating the discriminative stimulus effects of [baclofen] and [gamma hydroxybutyrate]. The study found that a [GABA B antagonist] significantly antagonized the discriminative stimulus effects of both drugs. These findings provide further evidence for the importance of [GABA B receptors] in the pharmacological actions of [baclofen] and [gamma hydroxybutyrate].

Understanding Drug Interactions is Crucial for Effective Treatment

This research highlights the importance of understanding drug interactions and the role of specific receptors in mediating their effects. The study emphasizes the need for careful consideration of potential interactions between [baclofen] and [gamma hydroxybutyrate] and other drugs that may act on [GABA B receptors]. This knowledge is crucial for ensuring safe and effective treatment outcomes.

Dr.Camel's Conclusion

This research explores the discriminative stimulus effects of [baclofen] and [gamma hydroxybutyrate] in mice, highlighting the importance of [GABA B receptors] in their pharmacological actions. The study provides valuable insights into the potential therapeutic applications of these drugs and the need for careful consideration of drug interactions.

Date :
  1. Date Completed 2022-08-12
  2. Date Revised 2023-09-02
Further Info :

Pubmed ID

35947069

DOI: Digital Object Identifier

NIHMS1824018

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