An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022.

Author: CilibrizziAgostino, CrocettiLetizia, FlorestaGiuseppe, GiovannoniMaria Paola

Paper Details 
Original Abstract of the Article :
Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the treatment of inflammation-based diseases. Several scientific advancements, by both academia and pharmaceutical companies, have enabled the identification of many synthetic ligands for this target, along with the ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370432/

データ提供:米国国立医学図書館(NLM)

PDE4 Inhibitors: A Promising Oasis in the Desert of Inflammation

Imagine a camel battling a persistent inflammation, like a stubborn desert rash. This is the experience of individuals with inflammatory conditions. This research explores the use of phosphodiesterase 4 (PDE4) inhibitors, like a powerful remedy in the desert, for treating inflammation-based diseases. The authors review the development of PDE4 inhibitors and their progress in clinical trials, highlighting the challenges and successes in bringing these therapies to patients. They discuss the various compounds that have reached clinical trials, including roflumilast for chronic obstructive pulmonary disease, crisaborole for atopic dermatitis, apremilast for psoriatic arthritis, and ibudilast for Krabbe disease. It's like a caravan of researchers, each contributing their expertise to find solutions for these debilitating conditions.

PDE4 Inhibitors: A New Frontier in Inflammation Treatment

This review highlights the potential of PDE4 inhibitors in treating inflammation-based diseases, offering a new frontier in therapeutic options. It's like discovering a new oasis in the desert, providing a source of relief and hope for those struggling with these conditions. This research emphasizes the importance of continued research and development of PDE4 inhibitors to address the unmet needs of patients with inflammatory conditions.

Navigating the Desert of Inflammation: PDE4 Inhibitors Offer Hope

PDE4 inhibitors, like a beacon of hope in the desert, offer a potential solution for individuals battling inflammation-based diseases. This review encourages further investigation into the development and use of PDE4 inhibitors to improve the lives of those affected by inflammatory conditions. It's like finding a new path through the desert, leading to a destination of healing and recovery.

Dr.Camel's Conclusion

This review highlights the potential of PDE4 inhibitors in treating inflammation-based diseases, offering a new frontier in therapeutic options. It's like discovering a new oasis in the desert, providing a source of relief and hope for those struggling with these conditions. This research emphasizes the importance of continued research and development of PDE4 inhibitors to address the unmet needs of patients with inflammatory conditions.

Date :
  1. Date Completed 2022-08-15
  2. Date Revised 2022-08-16
Further Info :

Pubmed ID

35956914

DOI: Digital Object Identifier

PMC9370432

SNS
PICO Info
in preparation
Languages

English

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