Apremilast exerts protective effects on stroke outcomes and blood-brain barrier (BBB) dysfunction through regulating Rho-associated protein kinase 2 expression.

Author: ChengZhihua, MengXiangyuan, WangMingyuan

Paper Details 
Original Abstract of the Article :
Stroke is a devastating event and a huge public health concern worldwide. Apremilast (APR) is a selective inhibitor of phosphodiesterase-4 involved in various neurological diseases, including stroke. However, the protective effects of APR on stroke have not been investigated. Here, we explored the e...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480930/

データ提供:米国国立医学図書館(NLM)

Apremilast: A Potential New Weapon in the Fight Against Stroke

The world of stroke research is a vast and complex landscape, with researchers constantly seeking new and improved ways to prevent, treat, and manage this devastating condition. This study delves into the potential of apremilast, a drug currently used to treat psoriasis, as a therapeutic agent for stroke.

Exploring the Protective Effects of Apremilast

This study explores the potential neuroprotective effects of apremilast in a mouse model of stroke. The researchers found that apremilast reduced stroke-induced brain damage and improved neurological outcomes, suggesting its potential as a therapeutic agent for stroke. Their findings also shed light on the mechanism by which apremilast exerts its protective effects, suggesting that it may regulate the expression of a specific protein involved in blood-brain barrier function.

A Beacon of Hope in the Desert of Stroke Research

The findings of this study offer a beacon of hope in the ongoing quest for effective stroke treatments. The researchers' discovery of apremilast's potential neuroprotective effects suggests that this drug, currently used to treat psoriasis, may also have therapeutic applications for stroke. This research, like a well-charted path through the desert of stroke research, guides us towards a future where we have more effective treatments for this debilitating condition.

Dr.Camel's Conclusion

This study offers a promising new avenue for stroke treatment, exploring the potential of apremilast to protect against brain damage and improve outcomes. Like a camel caravan venturing into a new territory, this research explores a promising new frontier in stroke research, offering hope for a brighter future for those affected by this devastating condition.

Date :
  1. Date Completed 2022-09-20
  2. Date Revised 2022-10-04
Further Info :

Pubmed ID

35971637

DOI: Digital Object Identifier

PMC9480930

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Languages

English

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