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TARC/CCL17 Expression Is Associated with CD8<sup>+</sup> T Cell Recruitment in Abacavir-Induced Skin Hypersensitivity in HLA-Transgenic Mice.

Author: AokiShigeki, GaoYuying, ItoKousei, KazaokaAkira, KuwaharaSaki

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the role of thymus and activation-regulated chemokine (TARC)/CCL17 in abacavir (ABC)-induced hypersensitivity (AHS) in a mouse model. Elevated serum TARC levels were associated with the severity of skin toxicity, suggesting its potential as a biomarker for AHS. Neutralization of TARC effectively alleviated skin toxicity symptoms.
Paper Details　
Original Abstract of the Article :
Abacavir (ABC)-induced hypersensitivity (AHS) is strongly associated with human leukocyte antigen (HLA)-B*57&#8201;:&#8201;01 expression. Previous studies have demonstrated the feasibility of applying the HLA-transgenic mouse model in this context. ABC-induced adverse reactions were observed in HLA-...See full text at original site
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引用元：
https://doi.org/10.1248/bpb.b22-00313

データ提供：米国国立医学図書館（NLM）

TARC/CCL17: A Potential Biomarker for Abacavir-Induced Hypersensitivity

Abacavir (ABC)-induced hypersensitivity (AHS), a severe adverse reaction to the antiretroviral drug abacavir, is a significant concern in the field of HIV treatment. This study investigates the role of TARC/CCL17, a chemokine involved in immune responses, in AHS. The researchers used HLA-transgenic mice, which express specific human leukocyte antigen (HLA) genes, to model AHS. Their findings indicate that TARC/CCL17 levels are elevated in mice with AHS and that TARC neutralization can alleviate symptoms, suggesting that TARC could be a potential biomarker for AHS.

TARC/CCL17: A Potential Target for AHS Management

This study provides valuable insights into the role of TARC/CCL17 in abacavir-induced hypersensitivity (AHS). The study's findings suggest that TARC/CCL17 levels are elevated in mice with AHS and that TARC neutralization can alleviate symptoms, highlighting its potential as a biomarker for AHS. These findings also suggest that TARC could be a potential target for therapeutic interventions aimed at managing AHS. Further research is needed to confirm these findings and to explore the potential of targeting TARC in humans.

TARC/CCL17: A Key Player in Abacavir-Induced Hypersensitivity

This study underscores the importance of understanding the role of chemokines in abacavir-induced hypersensitivity (AHS). The researchers found that TARC/CCL17 levels are elevated in mice with AHS and that TARC neutralization can alleviate symptoms, highlighting its potential as a biomarker for AHS. These findings emphasize the need for a more targeted approach to managing AHS, considering the specific role of chemokines in mediating this adverse reaction.

Dr.Camel's Conclusion

This study provides valuable insights into the role of TARC/CCL17 in abacavir-induced hypersensitivity (AHS). The findings suggest that TARC could be a potential biomarker for AHS and a potential target for therapeutic interventions aimed at managing this adverse reaction. This research highlights the importance of understanding the complex interplay between the immune system and drug-induced hypersensitivity, paving the way for more targeted and effective treatment strategies in the future.
Date :
  1. Date Completed 2022-09-08
  2. Date Revised 2022-09-09
Further Info :

Pubmed ID

36047204

DOI: Digital Object Identifier

10.1248/bpb.b22-00313

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Article Analysis
・Effects of abacavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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