Paper Details
- Home
- Paper Details
Identification of Fusion Genes and Targets for Genetically Matched Therapies in a Large Cohort of Salivary Gland Cancer Patients.
Author: EijkelenboomAstrid, GrünbergKatrien, JansenErik A M, KampingEveline J, LasscheGerben, LigtenbergMarjolijn J L, TjanMartijn J H, VerhaeghGerald W, van CleefPatricia H J, van Engen-van GrunsvenAdriana C H, van HelvertSjoerd, van HerpenCarla M L
Original Abstract of the Article :
<b>Introduction:</b> Salivary gland cancer (SGC) is a rare cancer for which systemic treatment options are limited. Therefore, it is important to characterize its genetic landscape in search for actionable aberrations, such as <i>NTRK</i> gene fusions. This research aimed to identify these actionab...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454424/
データ提供：米国国立医学図書館（NLM）
Unveiling Actionable Genetic Aberrations in Salivary Gland Cancer
Salivary gland cancer (SGC), a rare and challenging disease, often lacks effective systemic treatment options. This research, like a skilled surgeon meticulously dissecting a complex tumor, delves into the genetic landscape of SGC, seeking actionable aberrations that could guide targeted therapies. The researchers analyzed both RNA and DNA from 121 patients with various SGC subtypes, employing next-generation sequencing (NGS) to identify gene fusions and other genetic alterations. Their findings reveal a wealth of genetic information, including both known and previously unknown gene fusions, highlighting the intricate genetic heterogeneity of SGC. The study identifies specific actionable aberrations, such as mutations in PIK3CA, ERBB2, HRAS, and NOTCH1, suggesting potential targets for genetically matched therapies.
Precision Medicine for Salivary Gland Cancer
This study, like a skilled cartographer mapping a complex terrain, offers valuable insights into the genetic landscape of SGC, paving the way for personalized treatment approaches. The identification of actionable genetic aberrations presents a promising avenue for developing targeted therapies, potentially improving outcomes for patients with this rare and often challenging disease.
Navigating the Complexities of Salivary Gland Cancer Treatment
Salivary gland cancer is a complex and often challenging disease, requiring a multifaceted approach to treatment. This research underscores the importance of comprehensive genetic analysis in guiding therapeutic decisions, potentially leading to more effective and personalized treatments.
Dr.Camel's Conclusion
This research, like a desert oasis providing vital sustenance, unveils a wealth of genetic information about salivary gland cancer, paving the way for a more personalized approach to treatment. The identification of actionable genetic aberrations offers hope for patients seeking effective and tailored therapies.
Date :
- Date Completed n.d.
- Date Revised 2022-09-13
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.