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Drug-induced acne with elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis.

Author: HudsonBrionna N, JacobsHollyann R, PhilbrickAlexander, RotoloShannon M, SafirsteinJulie A, SimonsenMichelle M, ZhouXiaolong A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case series describes 19 patients who reported new onset or worsening of acne after starting treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulator elexacaftor/tezacaftor/ivacaftor (ELX-TEZ-IVA). The mechanism and frequency of this adverse effect are unknown.
Paper Details　
Original Abstract of the Article :
Elexacaftor/tezacaftor/ivacaftor (ELX-TEZ-IVA) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator shown to improve lung function and reduce sweat chloride in people with Cystic Fibrosis (CF). The only commonly reported dermatologic adverse effect with CFTR modulators including...See full text at original site
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引用元：
https://doi.org/10.1016/j.jcf.2022.09.002

データ提供：米国国立医学図書館（NLM）

Elexacaftor/Tezacaftor/Ivacaftor: A Potential Trigger for Acne in People with Cystic Fibrosis

Cystic fibrosis (CF), a genetic disorder affecting the lungs and other organs, presents unique challenges for patients. Elexacaftor/tezacaftor/ivacaftor (ELX-TEZ-IVA), a CFTR modulator, has shown promise in improving lung function and reducing sweat chloride in individuals with CF. However, this study explores a potential dermatologic adverse effect of this medication: acne. Researchers identified 19 patients who reported new onset or worsening of acne after initiating ELX-TEZ-IVA treatment.

Acne: A Newly Recognized Adverse Effect of ELX-TEZ-IVA

This study highlights a potential association between ELX-TEZ-IVA treatment and acne. While the exact mechanism and frequency of this adverse effect remain unknown, it is crucial for healthcare providers to be aware of this potential complication.

Navigating the Desert of Cystic Fibrosis: Unexpected Side Effects

Think of CF as a vast desert, where individuals face constant challenges and seek interventions to improve their well-being. ELX-TEZ-IVA, like a beacon of hope, can offer significant benefits, but it's important to be aware of potential unexpected side effects, such as acne, which may appear along the journey.

Dr. Camel's Conclusion

This study sheds light on a potentially overlooked adverse effect of ELX-TEZ-IVA treatment, underscoring the importance of continued monitoring for dermatologic complications in patients receiving this medication. Further research is needed to elucidate the mechanism of this adverse effect and develop strategies for minimizing its occurrence.

Date :
  1. Date Completed 2022-12-06
  2. Date Revised 2022-12-16
Further Info :

Pubmed ID

36088208

DOI: Digital Object Identifier

10.1016/j.jcf.2022.09.002

SNS
PICO Info
in preparation
Languages

English

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