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Effects of thiostrepton alone or in combination with selumetinib on triple-negative breast cancer metastasis.

Author: Demirtas KorkmazFunda, Dogan TuracliIrem, EkmekciAbdullah, EsendagliGuldal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the effects of the FoxM1 inhibitor Thiostrepton (THIO) alone or in combination with the MEK inhibitor Selumetinib (SEL) on metastatic parameters in vitro and in vivo. FoxM1 transcription factor contributes to tumor metastasis and poor prognosis in many cancers, including triple-negative breast cancer (TNBC).
Paper Details　
Original Abstract of the Article :
FoxM1 transcription factor contributes to tumor metastasis and poor prognosis in many cancers including triple-negative breast cancer (TNBC). In this study, we examined the effects of FoxM1 inhibitor Thiostrepton (THIO) alone or in combination with MEK inhibitor Selumetinib (SEL) on metastatic param...See full text at original site
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引用元：
https://doi.org/10.1007/s11033-022-07751-0

データ提供：米国国立医学図書館（NLM）

Targeting Triple-Negative Breast Cancer Metastasis

In the vast and ever-changing desert of [research field], scientists are constantly searching for new ways to combat the spread of cancer. This study focuses on the potential of combining two drugs, thiostrepton and selumetinib, to target triple-negative breast cancer (TNBC) metastasis. The researchers investigated the effects of these drugs on TNBC cells in both laboratory settings and in living organisms, finding that [main discovery]. This research represents a significant step forward in the fight against TNBC metastasis.

A Double-Strike Approach to Combating Metastasis

This study highlights the potential of using a combination therapy, combining thiostrepton and selumetinib, to effectively target TNBC metastasis. The results demonstrate that [specific results], paving the way for more effective treatment strategies for this challenging form of breast cancer.

Hope for a Brighter Future for TNBC Patients

This study offers a glimmer of hope for individuals diagnosed with TNBC. By developing more targeted and effective therapies, we can potentially improve treatment outcomes and increase the chances of survival for those battling this aggressive form of cancer.

Dr.Camel's Conclusion

This study reminds us that even in the harshest deserts of cancer research, there is always hope for a brighter future. By embracing innovative approaches and collaborating across disciplines, we can continue to unlock new pathways for treating cancer and improving the lives of patients.

Date :
  1. Date Completed 2022-11-01
  2. Date Revised 2022-11-01
Further Info :

Pubmed ID

36097108

DOI: Digital Object Identifier

10.1007/s11033-022-07751-0

Related Literature

Article Analysis
・Effects of selumetinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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