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An integrative systems biology approach to overcome venetoclax resistance in acute myeloid leukemia.

Author: CathelinSeverine, ChanSteven, KohandelMohammad, PrzedborskiMichelle, SharonDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This abstract investigates how to overcome drug resistance in AML using Bcl-2 inhibitors. It explains that inhibiting mitochondrial translation with tedizolid sensitizes drug-resistant AML cells to venetoclax. A mathematical model helps understand the molecular mechanisms behind this process, particularly the role of the integrated stress response (ISR).
Paper Details　
Original Abstract of the Article :
The over-expression of the Bcl-2 protein is a common feature of many solid cancers and hematological malignancies, and it is typically associated with poor prognosis and resistance to chemotherapy. Bcl-2-specific inhibitors, such as venetoclax, have recently been approved for the treatment of chroni...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469948/

データ提供：米国国立医学図書館（NLM）

Overcoming Drug Resistance in Acute Myeloid Leukemia: A Systems Biology Approach

Acute myeloid leukemia (AML), a type of blood cancer, can be challenging to treat due to drug resistance. This study explores a systems biology approach to overcome resistance to venetoclax, a targeted therapy for AML. The researchers investigate the role of the integrated stress response (ISR) in sensitizing resistant AML cells to venetoclax. Their findings suggest that inhibiting mitochondrial translation, which activates the ISR, can help overcome drug resistance. This research highlights the potential of a multi-pronged approach to combatting cancer.

A Multifaceted Approach to Cancer Treatment

This study is like navigating a vast desert, searching for multiple paths to overcome drug resistance in AML. The researchers, guided by systems biology principles, have identified a novel approach to sensitizing resistant cells to treatment. It's a reminder that a multi-faceted approach, considering various cellular pathways and processes, can be more effective than targeting a single pathway.

The Future of Cancer Treatment: A Multidisciplinary Landscape

This research highlights the importance of interdisciplinary collaboration in cancer research. By integrating various scientific fields, including molecular biology, genetics, and computational modeling, researchers are making significant progress in understanding and overcoming drug resistance. This collaborative effort is crucial to developing new therapies and improving patient outcomes.

Dr. Camel's Conclusion

This study provides valuable insights into the complexity of cancer treatment and the power of systems biology. It reminds us that the key to defeating cancer lies in a multidisciplinary approach, combining scientific knowledge and innovative technologies. This research offers hope for a future where drug resistance is a less formidable obstacle in the desert of cancer treatment.

Date :
  1. Date Completed 2022-09-15
  2. Date Revised 2022-09-27
Further Info :

Pubmed ID

36099249

DOI: Digital Object Identifier

PMC9469948

Related Literature

Article Analysis
・Effects of tedizolid
SNS
PICO Info
in preparation
Languages

English

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