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Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis.

Author: JiangHuimin, LiYanan, LiuWenwen, MiaoYiqun, WangAihua, ZhangYuanyuan, ZhaoShuliang, ZhouYun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis compared the efficacy and safety of caffeine citrate and aminophylline for apnea of prematurity. Both medications had similar therapeutic effectiveness on respiratory function, but caffeine was associated with fewer side effects, including tachycardia and feeding intolerance.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Methylxanthine, including caffeine citrate and aminophylline, is the most common pharmacologic treatment for apnea of prematurity. However, due to the lack of high-quality evidence, there are no clear recommendations or guidelines on how to choose between caffeine and aminophylline. OBJ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484669/

データ提供：米国国立医学図書館（NLM）

Choosing the Right Path: Comparing Caffeine Citrate and Aminophylline for Apnea of Prematurity

Treating apnea of prematurity can feel like navigating a desert of uncertainty, with various treatment options available. This research is like a compass, guiding us through the landscape of these options by comparing the efficacy and safety of caffeine citrate and aminophylline. The authors conducted a systematic review and meta-analysis of the existing literature, seeking to provide evidence-based recommendations for clinicians.

Caffeine Citrate and Aminophylline: Two Paths Through the Desert

This research is like a desert oasis, providing a comprehensive comparison of two common treatments for apnea of prematurity. The authors found that caffeine citrate and aminophylline have similar therapeutic effectiveness in improving respiratory function. However, they also noted that caffeine citrate was associated with fewer side effects, such as tachycardia and feeding intolerance. These findings suggest that caffeine citrate may be a preferable option for treating apnea of prematurity.

Finding the Best Path for Apnea of Prematurity Treatment

This research is a valuable tool for making informed decisions about the treatment of apnea of prematurity. The authors' findings suggest that caffeine citrate may offer a safer and more effective option compared to aminophylline. It's a reminder that the desert of medical treatments is vast and complex, and careful consideration is needed when choosing the best approach for individual patients.

Dr. Camel's Conclusion

This systematic review and meta-analysis provide valuable insights into the comparative efficacy and safety of caffeine citrate and aminophylline for treating apnea of prematurity. The authors' findings suggest that caffeine citrate may be a preferable option, offering a safer and more effective approach to managing this condition. This research is a testament to the importance of continuous evaluation and comparison in the pursuit of optimal medical treatments.
Date :
  1. Date Completed 2022-09-22
  2. Date Revised 2022-10-04
Further Info :

Pubmed ID

36121807

DOI: Digital Object Identifier

PMC9484669

Related Literature

Article Analysis
・Side Effects of aminophylline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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