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Protective effects of rivaroxaban against cisplatin-induced testicular damage in rats: Impact on oxidative stress, coagulation, and p-NF-κB/VCAM-1 signaling.

Author: Abo-SaifAli A, Abo-YoussefAmira M, MohamedWafaa R, ShafieySara I

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the protective effects of rivaroxaban, an anticoagulant, against testicular damage induced by cisplatin in rats. Rivaroxaban significantly attenuated cisplatin-induced testicular damage by suppressing oxidative stress, inflammation, and coagulation. The findings suggest that rivaroxaban may be a potential therapeutic agent for preventing or mitigating cisplatin-induced testicular damage.
Paper Details　
Original Abstract of the Article :
Coagulation is a main pathway in various diseases pathogenesis including testicular damage. This study evaluated rivaroxaban (RVX) protective effects in testicular impairment by cisplatin (CP). Rats were randomly allocated into five groups: Control, RVX (7 mg/kg/day), CP (10 mg/kg), RVX 5 mg + CP an...See full text at original site
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引用元：
https://doi.org/10.1016/j.fct.2022.113419

データ提供：米国国立医学図書館（NLM）

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Date :
  1. Date Completed 2022-10-21
  2. Date Revised 2022-10-21
Further Info :

Pubmed ID

36122812

DOI: Digital Object Identifier

10.1016/j.fct.2022.113419

Related Literature

Article Analysis
・Effects of rivaroxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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