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Efficacy of maintenance treatment in patients with multiple myeloma: a systematic review and network meta-analysis.

Author: BaoShuojing, ChaiGufan, ChenXi, LiuChengjiang, MaoJingcheng, ZhiYongjin, ZhuJianfeng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This network meta-analysis identified the most effective maintenance treatment for newly diagnosed multiple myeloma (NDMM) patients. Lenalidomide-carfilzomib was recommended as the best therapy for overall survival and progression-free survival, but it should be considered in light of increased adverse events and financial burden.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Despite conspicuous advances in innovating novel drugs and combination regimens in multiple myeloma (MM) in recent decades, the most appropriate maintenance regimens after inductive therapy are still controversial and opaque. OBJECTIVE: We aimed to identify the most effective maintenanc...See full text at original site
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引用元：
https://doi.org/10.1080/16078454.2022.2121900

データ提供：米国国立医学図書館（NLM）

Multiple Myeloma: A Quest for Optimal Maintenance Therapy

The field of [multiple myeloma treatment] has made significant strides in recent years, with the development of novel drugs and combination regimens. This study delves into the complex issue of [maintenance therapy] for patients with newly diagnosed multiple myeloma (NDMM). The authors conducted a comprehensive [systematic review and network meta-analysis] of clinical trials to identify the most effective maintenance regimens, providing valuable insights for clinicians seeking to optimize patient outcomes.

A Comprehensive Analysis: Identifying Optimal Maintenance Therapy

The study's findings highlight the efficacy of various maintenance therapies in prolonging overall survival (OS) and progression-free survival (PFS) in NDMM patients. Notably, [lenalidomide] and [daratumumab] emerged as effective maintenance treatments, showing significant benefits over placebo. The study also identified several combination regimens that demonstrated promising outcomes, including [lenalidomide-carfilzomib, lenalidomide-prednisone, bortezomib-thalidomide, and daratumumab].

Navigating the Complexities of Multiple Myeloma: Optimal Maintenance Therapy

This research provides valuable insights into the complex landscape of multiple myeloma treatment. The study's findings provide clinicians with a more comprehensive understanding of the effectiveness of various maintenance therapies, enabling them to make informed decisions regarding patient care. By carefully considering the individual patient's characteristics and risk factors, clinicians can select the most appropriate maintenance regimen, optimizing outcomes and improving quality of life for NDMM patients.

Dr. Camel's Conclusion

Like a camel navigating the challenging desert of multiple myeloma, researchers are constantly seeking new and effective treatment approaches. This study sheds light on the complex world of maintenance therapy, providing clinicians with valuable guidance for selecting the most appropriate treatment options for NDMM patients. By leveraging this research, we can improve the lives of individuals facing this challenging condition.

Date :
  1. Date Completed 2022-09-22
  2. Date Revised 2022-09-22
Further Info :

Pubmed ID

36125238

DOI: Digital Object Identifier

10.1080/16078454.2022.2121900

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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